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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1u54 ACP Activated CDC42 kinase 1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1u54 ACPActivated CDC42 kinase 1 / 0.960
2pz5 ACPFibroblast growth factor receptor 2 / 0.759
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.741
2py3 ACPFibroblast growth factor receptor 2 / 0.722
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.720
2pzp ACPFibroblast growth factor receptor 2 / 0.718
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.715
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.714
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.713
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.712
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.712
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.711
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.710
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.709
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.706
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.705
2olc ADPMethylthioribose kinase 2.7.1.100 0.705
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.704
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.703
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.703
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.702
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.700
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.699
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.697
3q5i ANPProtein kinase, putative / 0.696
3cly ACPFibroblast growth factor receptor 2 / 0.694
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.694
1ol6 ATPAurora kinase A 2.7.11.1 0.693
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.693
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.692
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.691
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.691
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.690
2pul ACPMethylthioribose kinase 2.7.1.100 0.690
4bn1 ADPAurora kinase A 2.7.11.1 0.689
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.689
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.688
2dwb ANPAurora kinase A 2.7.11.1 0.688
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.688
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
2pui ADPMethylthioribose kinase 2.7.1.100 0.687
2pyw ADPMethylthioribose kinase 2.7.1.100 0.687
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.687
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.686
4q5h ANPProtein kinase OspG 2.7 0.686
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.685
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.685
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.684
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.684
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.684
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.683
3qc9 ADPRhodopsin kinase / 0.680
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.678
2pun ACPMethylthioribose kinase 2.7.1.100 0.678
5dt4 ATPAurora kinase A 2.7.11.1 0.678
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.677
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.677
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.676
2wqe ADPAurora kinase A 2.7.11.1 0.676
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.676
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.675
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.675
3b2t M33Fibroblast growth factor receptor 2 / 0.675
5csh ATPCasein kinase II subunit alpha 2.7.11.1 0.675
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.674
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.674
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.674
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.673
5dos ATPAurora kinase A 2.7.11.1 0.673
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.672
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.672
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.672
4jrn ANPRhoptry kinase family protein / 0.672
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.671
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.671
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.671
4o4d ATPKinase / 0.671
3t8o ATPRhodopsin kinase / 0.670
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.670
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.669
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.668
2pup ADPMethylthioribose kinase 2.7.1.100 0.668
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.667
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.667
5dt3 ATPAurora kinase A 2.7.11.1 0.667
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.666
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.666
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.666
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.665
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.665
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.665
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.664
4qny ANPMitogen activated protein kinase, putative / 0.664
4s34 ANPMitogen-activated protein kinase 1 2.7.11.24 0.664
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.664
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.663
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.663
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.662
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.662
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.662
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
5drd ATPAurora kinase A 2.7.11.1 0.661
5l8l ADPAurora kinase A 2.7.11.1 0.661
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.660
2pml ANPUncharacterized protein / 0.660
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.660
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.660
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.659
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
4c3r ACPAurora kinase A 2.7.11.1 0.659
4ogr ADNCyclin-dependent kinase 9 2.7.11.22 0.659
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.659
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.659
5l8j ADPAurora kinase A 2.7.11.1 0.659
1i44 ACPInsulin receptor 2.7.10.1 0.658
2pwl ACPFibroblast growth factor receptor 2 / 0.658
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.658
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
5dr2 ATPAurora kinase A 2.7.11.1 0.658
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.657
2eb3 ANPEpidermal growth factor receptor 2.7.10.1 0.656
3orl AGSSerine/threonine protein kinase / 0.656
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
2hgs ADPGlutathione synthetase 6.3.2.3 0.654
5dnr ATPAurora kinase A 2.7.11.1 0.654
1fin ATPCyclin-dependent kinase 2 2.7.11.22 0.653
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.653
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.653
3orp AGSSerine/threonine protein kinase / 0.653
4dee ADPAurora kinase A 2.7.11.1 0.653
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.653
1w8c N69Cyclin-dependent kinase 2 2.7.11.22 0.652
3c4z ADPRhodopsin kinase / 0.652
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.652
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.652
4xlv ACPInsulin receptor 2.7.10.1 0.652
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.651
4gv1 0XZRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.651
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.651
4q5j ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.651
5ce3 ADPProtein kinase YopO / 0.651
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.650
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.650