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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1u4s BIH L-lactate dehydrogenase 1.1.1.27

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1u4s BIHL-lactate dehydrogenase 1.1.1.27 0.814
1u5a BIKL-lactate dehydrogenase 1.1.1.27 0.741
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.686
2nli FMNLactate oxidase / 0.672
3kkz SAMUncharacterized protein / 0.672
2r59 PH0Leukotriene A-4 hydrolase 3.3.2.6 0.668
2zfa FMNLactate oxidase / 0.668
1dyj DDFDihydrofolate reductase 1.5.1.3 0.666
3lcu SAH16S rRNA (guanine(1405)-N(7))-methyltransferase 2.1.1.179 0.666
4bqy FNTEgl nine homolog 1 / 0.666
2r2n KYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.665
4ph9 IBPProstaglandin G/H synthase 2 1.14.99.1 0.665
1eqh FLPProstaglandin G/H synthase 1 1.14.99.1 0.664
1toi HCIAspartate aminotransferase 2.6.1.1 0.664
3zky WT4Isopenicillin N synthase 1.21.3.1 0.662
3td8 D2RDihydrofolate reductase 1.5.1.3 0.661
2ay5 IOPAromatic-amino-acid aminotransferase 2.6.1.57 0.658
3kh5 ADPUncharacterized protein MJ1225 / 0.656
4i6a HMG3-hydroxy-3-methylglutaryl-coenzyme A reductase 1.1.1.88 0.656
1d3g BREDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.655
4x5f FOLDihydrofolate reductase 1.5.1.3 0.655
1vso AT1Glutamate receptor ionotropic, kainate 1 / 0.654
1khz ADVADP-ribose pyrophosphatase 3.6.1.13 0.653
3mvz BHNNickel-binding periplasmic protein / 0.653
4l8u 9AZSerum albumin / 0.653
4nhm UN9Prolyl 3,4-dihydroxylase TPA1 1.14.11 0.653
3mw0 BHRNickel-binding periplasmic protein / 0.651
4i3p 1CW3-hydroxyanthranilate 3,4-dioxygenase / 0.651
4iwn GEKCarboxy-S-adenosyl-L-methionine synthase / 0.651