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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1u08 PLP Methionine aminotransferase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1u08 PLPMethionine aminotransferase / 1.146
4wlj IK2Kynurenine--oxoglutarate transaminase 1 2.6.1.7 0.878
4ge7 0K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.843
4geb 0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.832
4w5k PLPAspartate aminotransferase, mitochondrial / 0.804
4ge9 0L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.798
4ge4 0KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.778
3ele PLPAminotransferase / 0.743
4emy PLPAminotransferase class I and II / 0.725
4gdy 0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.723
4fl0 PLPAminotransferase ALD1, chloroplastic 2.6.1 0.708
2bwp PLG5-aminolevulinate synthase 2.3.1.37 0.703
1arg PPDAspartate aminotransferase 2.6.1.1 0.702
3vax PLPUncharacterized protein / 0.692
3tqx PLP2-amino-3-ketobutyrate coenzyme A ligase / 0.674
4je5 PLPAromatic/aminoadipate aminotransferase 1 2.6.1.39 0.673
2hp2 KE4Glutamate-1-semialdehyde 2,1-aminomutase 5.4.3.8 0.670
4aoa IK2Beta-phenylalanine transaminase 2.6.1 0.667
1maq PGUAspartate aminotransferase, mitochondrial 2.6.1.1 0.664
1j0d 5PA1-aminocyclopropane-1-carboxylate deaminase 3.5.99.7 0.662
1map KETAspartate aminotransferase, mitochondrial 2.6.1.1 0.659
4adc PLPSuccinylornithine transaminase 2.6.1.81 0.658
1cq6 PY4Aspartate aminotransferase 2.6.1.1 0.657
1wkh PPE[LysW]-aminoadipate semialdehyde transaminase / 0.656
5k8b PDG8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase / 0.654
4jf1 PLPAcetylornithine/succinyldiaminopimelate aminotransferase 2.6.1.11 0.653
3lbo LDTAldose reductase 1.1.1.21 0.650