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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1tsx UMP Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1tsx UMPThymidylate synthase / 1.014
1tsy UMPThymidylate synthase / 0.918
1bid UMPThymidylate synthase / 0.874
1vzb UMPThymidylate synthase / 0.847
1njd UMPThymidylate synthase / 0.841
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.827
1bp6 UMPThymidylate synthase / 0.822
2tdm UMPThymidylate synthase / 0.822
1tsv UMPThymidylate synthase / 0.820
1njc DCMThymidylate synthase / 0.799
1f28 UMPThymidylate synthase 2.1.1.45 0.795
2g86 UMPThymidylate synthase / 0.790
1tys TMPThymidylate synthase / 0.778
4dq1 UMPThymidylate synthase / 0.778
2g8a UMPThymidylate synthase / 0.771
4fox UMPThymidylate synthase ThyA / 0.771
1nja DCMThymidylate synthase / 0.768
5by6 UMPThymidylate synthase / 0.767
1jmf UMPThymidylate synthase / 0.764
3bgx TMPThymidylate synthase / 0.762
2g8d UMPThymidylate synthase / 0.760
2g89 UMPThymidylate synthase / 0.757
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.750
4e5o UMPThymidylate synthase 2.1.1.45 0.750
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.749
1bpj UMPThymidylate synthase / 0.746
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.737
1jmi UMPThymidylate synthase / 0.736
2tsr UMPThymidylate synthase 2.1.1.45 0.735
4ein NOHThymidylate synthase 2.1.1.45 0.734
1jmg UMPThymidylate synthase / 0.733
1vza UMPThymidylate synthase / 0.728
2fto TMPThymidylate synthase / 0.728
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.724
1jmh UMPThymidylate synthase / 0.718
4irr UMPThymidylate synthase / 0.710
1bdu DURThymidylate synthase / 0.703
1nje DCMThymidylate synthase / 0.701
4iqq UMPThymidylate synthase / 0.697
1bp0 UMPThymidylate synthase / 0.693
1njb UMPThymidylate synthase / 0.693
1ddu DDUThymidylate synthase / 0.690
2vet UMPThymidylate synthase / 0.683
4h0u UMPThymidylate synthase / 0.678
4psg NOHThymidylate synthase / 0.677
1thy UMPThymidylate synthase / 0.673
1aob DDUThymidylate synthase / 0.672
4ocg COAFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.659
4eb4 UMPThymidylate synthase 2.1.1.45 0.653