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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1tka N3T Transketolase 1 2.2.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1tka N3TTransketolase 1 2.2.1.1 1.089
1tkb N1TTransketolase 1 2.2.1.1 0.872
2r5n TPPTransketolase 1 / 0.858
3upt TPPTransketolase / 0.847
1trk TPPTransketolase 1 2.2.1.1 0.846
1gpu THDTransketolase 1 2.2.1.1 0.816
1ngs TPPTransketolase 1 2.2.1.1 0.809
1ay0 TPPTransketolase 1 2.2.1.1 0.784
1itz TPPTransketolase, chloroplastic 2.2.1.1 0.780
3m6l TPPTransketolase / 0.779
3m34 TPPTransketolase / 0.769
2r8p T6FTransketolase 1 / 0.746
1tkc M6TTransketolase 1 2.2.1.1 0.732
4c7x TPPTransketolase / 0.723
3rim TPPTransketolase 2.2.1.1 0.717
2r8o T5XTransketolase 1 / 0.715
3m7i TPPTransketolase / 0.715
1ni4 TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.656
1ni4 TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.656