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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1thn ADP Anti-sigma F factor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1thn ADPAnti-sigma F factor / 1.029
3a0t ADPSensor histidine kinase / 0.748
2zkj ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.729
1gjv AGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.7.11.4 0.718
3d2r ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.714
2zdy ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.704
1th8 ADPAnti-sigma F factor / 0.701
1z5a ADPType 2 DNA topoisomerase 6 subunit B / 0.677
3sl2 ATPSensor histidine kinase WalK / 0.677
1i59 ANPChemotaxis protein CheA 2.7.13.3 0.671
1i5a ACPChemotaxis protein CheA 2.7.13.3 0.664
1i5b ANPChemotaxis protein CheA 2.7.13.3 0.664
2vfz UPFN-acetyllactosaminide alpha-1,3-galactosyltransferase / 0.662
4gt8 ADPSensor protein VraS 2.7.13.3 0.658
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.656
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.654
1xjn CDPVitamin B12-dependent ribonucleotide reductase / 0.653
2c2a ADPSensor histidine kinase / 0.652
4prx ADPDNA gyrase subunit B / 0.652