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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1tdr MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1tdr MTXDihydrofolate reductase 1.5.1.3 1.067
2drc MTXDihydrofolate reductase 1.5.1.3 0.915
4dfr MTXDihydrofolate reductase 1.5.1.3 0.900
1dra MTXDihydrofolate reductase 1.5.1.3 0.896
3drc MTXDihydrofolate reductase 1.5.1.3 0.892
5hi6 MTXDihydrofolate reductase / 0.865
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.861
3dau MTXDihydrofolate reductase 1.5.1.3 0.856
3dfr MTXDihydrofolate reductase 1.5.1.3 0.854
4p66 MTXDihydrofolate reductase / 0.842
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.840
3och 2MXDihydrofolate reductase 1.5.1.3 0.840
1df7 MTXDihydrofolate reductase 1.5.1.3 0.817
1drb MTXDihydrofolate reductase 1.5.1.3 0.816
3tq9 MTXDihydrofolate reductase / 0.813
1dhi MTXDihydrofolate reductase 1.5.1.3 0.805
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.804
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.801
4qi9 MTXDihydrofolate reductase / 0.798
1dre MTXDihydrofolate reductase 1.5.1.3 0.787
1dls MTXDihydrofolate reductase 1.5.1.3 0.786
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.785
1ohj COPDihydrofolate reductase 1.5.1.3 0.779
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.778
1dyi FOLDihydrofolate reductase 1.5.1.3 0.776
4x5g FOLDihydrofolate reductase 1.5.1.3 0.776
2zza FOLDihydrofolate reductase / 0.775
3eig MTXDihydrofolate reductase 1.5.1.3 0.775
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.774
1dyh DZFDihydrofolate reductase 1.5.1.3 0.771
4kjj FOLDihydrofolate reductase 1.5.1.3 0.770
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.769
4x5h FOLDihydrofolate reductase 1.5.1.3 0.768
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.765
1u70 MTXDihydrofolate reductase 1.5.1.3 0.762
7dfr FOLDihydrofolate reductase 1.5.1.3 0.756
2qk8 MTXDihydrofolate reductase / 0.755
1drf FOLDihydrofolate reductase 1.5.1.3 0.751
1jol FFODihydrofolate reductase 1.5.1.3 0.744
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.741
4m6k FOLDihydrofolate reductase 1.5.1.3 0.741
4x5f FOLDihydrofolate reductase 1.5.1.3 0.738
5ccc DDFDihydrofolate reductase 1.5.1.3 0.732
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.726
1ddr MTXDihydrofolate reductase 1.5.1.3 0.725
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.723
2d0k FOLDihydrofolate reductase 1.5.1.3 0.722
2dhf DZFDihydrofolate reductase 1.5.1.3 0.722
4x5i FOLDihydrofolate reductase 1.5.1.3 0.721
3ia4 MTXDihydrofolate reductase / 0.720
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.719
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.717
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.717
4p68 MTXDihydrofolate reductase / 0.717
1u72 MTXDihydrofolate reductase 1.5.1.3 0.716
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.713
1e26 GPBDihydrofolate reductase 1.5.1.3 0.713
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.713
1dhj MTXDihydrofolate reductase 1.5.1.3 0.712
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.710
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.710
1dyj DDFDihydrofolate reductase 1.5.1.3 0.709
1dds MTXDihydrofolate reductase 1.5.1.3 0.707
4i1n FOLDihydrofolate reductase 1.5.1.3 0.707
3dat MTXDihydrofolate reductase / 0.706
3tqb FOLDihydrofolate reductase / 0.703
4keb FOLDihydrofolate reductase 1.5.1.3 0.702
1hfq MOTDihydrofolate reductase 1.5.1.3 0.700
1hfr MOTDihydrofolate reductase 1.5.1.3 0.698
4fhb FOLDihydrofolate reductase 1.5.1.3 0.697
1hfp MOTDihydrofolate reductase 1.5.1.3 0.695
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.694
4i13 FOLDihydrofolate reductase 1.5.1.3 0.694
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.692
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.685
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.685
4kfj FOLDihydrofolate reductase 1.5.1.3 0.684
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.681
1dhf FOLDihydrofolate reductase 1.5.1.3 0.680
3tq8 TOPDihydrofolate reductase / 0.678
3fl8 RARDihydrofolate reductase / 0.676
4m7v RARDihydrofolate reductase / 0.670
2w9g TOPDihydrofolate reductase 1.5.1.3 0.668
3ghw GHWDihydrofolate reductase 1.5.1.3 0.668
3fyw XCFDihydrofolate reductase 1.5.1.3 0.664
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.664
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.664
2w3v TOPDihydrofolate reductase / 0.658
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.657
1re7 FOLDihydrofolate reductase 1.5.1.3 0.657
2w3m FOLDihydrofolate reductase 1.5.1.3 0.657
4elf 35IDihydrofolate reductase / 0.657
4elh 53IDihydrofolate reductase / 0.656
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.651
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.650
3zky WT4Isopenicillin N synthase 1.21.3.1 0.650
4ele 31IDihydrofolate reductase / 0.650