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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1t2c NAI L-lactate dehydrogenase 1.1.1.27

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1t2c NAIL-lactate dehydrogenase 1.1.1.27 1.048
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.994
2a92 NAIL-lactate dehydrogenase / 0.953
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.901
1pzh NADLactate dehydrogenase / 0.885
1sow NADL-lactate dehydrogenase 1.1.1.27 0.878
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.864
2aa3 AP0L-lactate dehydrogenase / 0.860
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.857
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.856
4ros APRMalate dehydrogenase / 0.830
1bdm NAXMalate dehydrogenase / 0.827
1pzf A3DLactate dehydrogenase / 0.818
1pzg A3DLactate dehydrogenase / 0.815
1uxk NADMalate dehydrogenase / 0.809
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.806
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.772
5a1t NAIL-lactate dehydrogenase / 0.767
1uxj NADMalate dehydrogenase / 0.766
2x0i NAIMalate dehydrogenase / 0.760
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.757
1gv0 NADMalate dehydrogenase / 0.755
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.749
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.749
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.744
1wze NADMalate dehydrogenase / 0.743
2p9g NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.740
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.737
1ib6 NADMalate dehydrogenase / 0.735
1guy NADMalate dehydrogenase / 0.731
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.729
3gvh NADMalate dehydrogenase / 0.729
1b8v NADMalate dehydrogenase / 0.727
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.727
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.726
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.724
1o6z NADMalate dehydrogenase / 0.723
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.722
1bmd NADMalate dehydrogenase / 0.721
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.719
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.719
1dxy NADD-2-hydroxyisocaproate dehydrogenase 1.1.1 0.718
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.717
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.717
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.715
1wzi NDPMalate dehydrogenase / 0.714
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.712
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.711
4i1i NADMalate dehydrogenase / 0.709
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.709
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.707
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.706
2vhx NADAlanine dehydrogenase 1.4.1.1 0.705
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.702
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.701
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.700
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.700
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.698
1f8f NADBenzyl alcohol dehydrogenase / 0.696
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.696
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.696
3uko NADAlcohol dehydrogenase class-3 / 0.695
1c1d NAIPhenylalanine dehydrogenase / 0.692
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.691
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.691
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.691
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.690
1hku NADC-terminal-binding protein 1 1.1.1 0.688
1ur5 NADMalate dehydrogenase / 0.688
4wlo NAIMalate dehydrogenase, mitochondrial 1.1.1.37 0.688
1x7d NADPutative ornithine cyclodeaminase / 0.686
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.686
4gl4 NAIAlcohol dehydrogenase class-3 / 0.686
4jji NADAlcohol dehydrogenase class-3 / 0.684
4uun NAIL-lactate dehydrogenase / 0.684
4j4b NAIUncharacterized protein / 0.683
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.682
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.679
3nt4 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.677
2vyn NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.674
4cpd NADAlcohol dehydrogenase / 0.674
1f17 NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.673
1u7h NADPutative ornithine cyclodeaminase / 0.673
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.673
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.672
2hu2 NADC-terminal binding protein 1 / 0.672
2dvm NAD439aa long hypothetical malate oxidoreductase (NAD) [malic enzyme] / 0.671
3gvi ADPMalate dehydrogenase / 0.671
3cif NADGlyceraldehyde-3-phosphate dehydrogenase / 0.670
3doc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.670
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.670
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.669
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.669
3kb6 NADD-lactate dehydrogenase / 0.669
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.668
3oet NADErythronate-4-phosphate dehydrogenase / 0.668
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.666
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.666
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.665
1nqa NADGlyceraldehyde-3-phosphate dehydrogenase / 0.663
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.663
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.662
1szj NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.662
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.662
2o4c NADErythronate-4-phosphate dehydrogenase / 0.661
4z0p NDPNAD-dependent dehydrogenase / 0.661
1gad NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.660
1ie3 NADMalate dehydrogenase / 0.660
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.656
4j43 NADUncharacterized protein / 0.656
1y7t NDPMalate dehydrogenase / 0.654
1e3e NAIAlcohol dehydrogenase 4 1.1.1.1 0.653
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.653
2ome NADC-terminal-binding protein 2 / 0.653
1h2h NADL-aspartate dehydrogenase 1.4.1.21 0.652
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.652
4cr8 NADN-acylmannosamine 1-dehydrogenase 1.1.1.233 0.652
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.651