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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1snu STU Tyrosine-protein kinase ITK/TSK 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.902
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.827
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.780
3zew STUEphrin type-B receptor 4 2.7.10.1 0.770
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.765
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.744
1n35 CH1RNA-directed RNA polymerase lambda-3 2.7.7.48 0.744
1n38 U3HRNA-directed RNA polymerase lambda-3 2.7.7.48 0.744
1nmd ATPMajor actin / 0.744
1wet GUNHTH-type transcriptional repressor PurR / 0.744
1xxj UNCUricase 1.7.3.3 0.744
2d09 FLVBiflaviolin synthase CYP158A2 / 0.744
2jey HLOAcetylcholinesterase 3.1.1.7 0.744
2oap ANPType II secretion system protein (GspE-2) / 0.744
3f8r NAPNADH oxidase/thioredoxin reductase / 0.744
3fzf ATPHeat shock cognate 71 kDa protein / 0.744
3u9d ATPActin, alpha skeletal muscle / 0.744
3ypi PGHTriosephosphate isomerase 5.3.1.1 0.744
3zzn ADPL-lactate dehydrogenase / 0.744
5bnt NAPAspartate-semialdehyde dehydrogenase 1.2.1.11 0.744
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.739
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.735
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.732
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.719
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.717
3a62 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.711
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.705
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.703
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.702
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.700
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.697
1byg STUTyrosine-protein kinase CSK / 0.689
1xjd STUProtein kinase C theta type 2.7.11.13 0.689
2j0k 4STFocal adhesion kinase 1 2.7.10.2 0.684
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.683
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.677
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.673
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.670
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.667
3d7t STUTyrosine-protein kinase CSK / 0.667
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.666
1fp6 ADPNitrogenase iron protein 1 1.18.6.1 0.660
1h48 C5P2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4.6.1.12 0.660
1yra GDPGPN-loop GTPase PAB0955 / 0.660
2hru ADPPhosphoribosylformylglycinamidine synthase subunit PurL / 0.660
2hs4 ACPPhosphoribosylformylglycinamidine synthase subunit PurL / 0.660
2xtn GTPGTPase IMAP family member 2 / 0.660
3fwy ADPLight-independent protochlorophyllide reductase iron-sulfur ATP-binding protein / 0.660
3kjg ADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC / 0.660
4cdg ADPBloom syndrome protein 3.6.4.12 0.660
4nxv GDPMitochondrial dynamics protein MID51 / 0.660
4nxx GDPMitochondrial dynamics protein MID51 / 0.660
4o3m ADPBloom syndrome protein 3.6.4.12 0.660
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.655
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.653
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.650