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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1s22 ATP Actin, alpha skeletal muscle

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1s22 ATPActin, alpha skeletal muscle / 1.181
1qz5 ATPActin, alpha skeletal muscle / 1.176
4k41 ATPActin, alpha skeletal muscle / 1.176
4pkg ATPActin, alpha skeletal muscle / 1.160
1t44 ATPActin, alpha skeletal muscle / 1.141
1c0f ATPMajor actin / 1.134
1dej ATPMajor actin / 1.121
4b1v ATPActin, alpha skeletal muscle / 1.115
3m6g ATPActin, alpha skeletal muscle / 1.110
4pki ATPActin, alpha skeletal muscle / 1.107
1wua ATPActin, alpha skeletal muscle / 1.099
4pl8 ATPActin, alpha skeletal muscle / 1.089
2q36 ATPActin, alpha skeletal muscle / 1.087
3a5o ATPMajor actin / 1.083
1eqy ATPActin, alpha skeletal muscle / 1.069
3w3d ATPActin, gamma-enteric smooth muscle / 1.066
3mn9 ATPActin-5C / 1.052
2v51 ATPActin, alpha skeletal muscle / 1.051
3m1f ATPActin, alpha skeletal muscle / 1.048
3tu5 ATPActin, alpha skeletal muscle / 1.038
3chw ATPMajor actin / 1.032
2q97 ATPActin, alpha skeletal muscle / 1.031
3mn7 ATPActin-5C / 1.029
3mn6 ATPActin-5C / 1.020
3eku ATPActin-5C / 1.016
3eks ATPActin-5C / 1.015
3ffk ATPActin, alpha skeletal muscle / 1.007
1rgi ATPActin, alpha skeletal muscle / 1.002
1kxp ATPActin, alpha skeletal muscle / 1.001
5ce3 ATPActin / 1.000
1mdu ATPActin, alpha skeletal muscle / 0.996
4cbx ATPActin-2 / 0.987
3el2 ATPActin-5C / 0.964
2oan ATPActin, cytoplasmic 1 / 0.961
3daw ATPActin, alpha skeletal muscle / 0.960
2a41 ATPActin, alpha skeletal muscle / 0.947
2p9k ATPActin-related protein 2 / 0.942
1nlv ATPMajor actin / 0.936
4ci6 ATPActin / 0.909
1h1v ATPActin, alpha skeletal muscle / 0.908
1atn ATPActin, alpha skeletal muscle / 0.907
1lot ATPActin, alpha skeletal muscle / 0.904
3wt0 ATPCell division protein FtsA / 0.904
4pkh ADPActin, alpha skeletal muscle / 0.892
4b9q ATPChaperone protein DnaK / 0.850
4m63 ATPActin-5C / 0.832
1rfq ATPActin, alpha skeletal muscle / 0.810
4ehu ANP2-hydroxyisocaproyl-CoA dehydratase activator / 0.806
3d2e ATPHeat shock protein homolog SSE1 / 0.805
4k42 ADPActin, alpha skeletal muscle / 0.795
3a5m ATPMajor actin / 0.789
1yxq ATPActin, alpha skeletal muscle / 0.786
4eht ADP2-hydroxyisocaproyl-CoA dehydratase activator / 0.775
3wqt ANPCell division protein FtsA / 0.765
1nmd ATPMajor actin / 0.758
1ijj ATPActin, alpha skeletal muscle / 0.744
1nm1 ATPMajor actin / 0.744
3ule ATPActin-related protein 2 / 0.741
2e2q ADPATP-dependent hexokinase / 0.736
4a62 ANPPlasmid segregation protein ParM / 0.729
4brd ANPEctonucleoside triphosphate diphosphohydrolase I / 0.727
4jhd ANPActin-5C / 0.726
4a61 ANPPlasmid segregation protein ParM / 0.719
5f1x ATP78 kDa glucose-regulated protein / 0.719
3ldl ATP78 kDa glucose-regulated protein / 0.717
5bsm ATP4-coumarate--CoA ligase 2 6.2.1.12 0.717
4brg GNPEctonucleoside triphosphate diphosphohydrolase I / 0.714
2d0o ADPDiol dehydratase-reactivating factor alpha subunit / 0.708
1ngd ADPHeat shock cognate 71 kDa protein / 0.705
3fe1 ADPHeat shock 70 kDa protein 6 / 0.705
4k43 ADPActin, alpha skeletal muscle / 0.705
3ldo ANP78 kDa glucose-regulated protein / 0.704
4bri UNPEctonucleoside triphosphate diphosphohydrolase I / 0.702
2zgy GDPPlasmid segregation protein ParM / 0.691
1mwm ADPPlasmid segregation protein ParM / 0.689
2zgz GNPPlasmid segregation protein ParM / 0.684
3u4l ATPActin, cytoplasmic 1 / 0.683
1nge ATPHeat shock cognate 71 kDa protein / 0.677
3u9d ATPActin, alpha skeletal muscle / 0.675
2fsn ADPArchaeal actin homolog / 0.672
2a84 ATPPantothenate synthetase 6.3.2.1 0.671
2qwn ADPHeat shock cognate 71 kDa protein / 0.671
4yj2 GTPTubulin alpha-1B chain / 0.671
3ryh GTPTubulin alpha chain / 0.668
3ub5 ATPActin, cytoplasmic 1 / 0.668
2pz8 APCNH(3)-dependent NAD(+) synthetase / 0.662
4dwb 0M7Farnesyl pyrophosphate synthase / 0.662
3bxz ADPProtein translocase subunit SecA / 0.659
3ez3 IPEFarnesyl pyrophosphate synthase, putative / 0.659
4fyx UTPAspartate carbamoyltransferase regulatory chain / 0.659
3ldw IPEFarnesyl pyrophosphate synthase, putative / 0.656
4nke IPEFarnesyl pyrophosphate synthase 2.5.1.10 0.655
4ymv ATPABC-type polar amino acid transport system, ATPase component / 0.654
4pxz CLRP2Y purinoceptor 12 / 0.653
4tuy GTPTubulin alpha-1B chain / 0.653
4du6 GTPGTP cyclohydrolase 1 / 0.652
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.651
3wqu ATPCell division protein FtsA / 0.651
5i9e ATPActin-related protein 4 / 0.650
5itz GTPTubulin alpha-1B chain / 0.650