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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rx6 DDF Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1rx6 DDFDihydrofolate reductase 1.5.1.3 1.051
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.983
5ccc DDFDihydrofolate reductase 1.5.1.3 0.908
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.865
1dyj DDFDihydrofolate reductase 1.5.1.3 0.841
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.809
7dfr FOLDihydrofolate reductase 1.5.1.3 0.803
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.798
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.790
1jom FFODihydrofolate reductase 1.5.1.3 0.789
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.788
1hfr MOTDihydrofolate reductase 1.5.1.3 0.784
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.773
1dyi FOLDihydrofolate reductase 1.5.1.3 0.771
4kjj FOLDihydrofolate reductase 1.5.1.3 0.770
4x5g FOLDihydrofolate reductase 1.5.1.3 0.768
1hfq MOTDihydrofolate reductase 1.5.1.3 0.764
4i13 FOLDihydrofolate reductase 1.5.1.3 0.760
1hfp MOTDihydrofolate reductase 1.5.1.3 0.757
4x5h FOLDihydrofolate reductase 1.5.1.3 0.757
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.756
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.754
1e26 GPBDihydrofolate reductase 1.5.1.3 0.750
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.738
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.728
4i1n FOLDihydrofolate reductase 1.5.1.3 0.727
4keb FOLDihydrofolate reductase 1.5.1.3 0.725
1drb MTXDihydrofolate reductase 1.5.1.3 0.724
1u72 MTXDihydrofolate reductase 1.5.1.3 0.724
4kfj FOLDihydrofolate reductase 1.5.1.3 0.724
3tqb FOLDihydrofolate reductase / 0.722
2d0k FOLDihydrofolate reductase 1.5.1.3 0.721
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.721
2zza FOLDihydrofolate reductase / 0.718
1dhf FOLDihydrofolate reductase 1.5.1.3 0.716
4m6k FOLDihydrofolate reductase 1.5.1.3 0.715
1df7 MTXDihydrofolate reductase 1.5.1.3 0.714
1dhj MTXDihydrofolate reductase 1.5.1.3 0.712
1u70 MTXDihydrofolate reductase 1.5.1.3 0.712
4x5i FOLDihydrofolate reductase 1.5.1.3 0.712
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.711
1dhi MTXDihydrofolate reductase 1.5.1.3 0.710
1dls MTXDihydrofolate reductase 1.5.1.3 0.710
1tdr MTXDihydrofolate reductase 1.5.1.3 0.710
3ghw GHWDihydrofolate reductase 1.5.1.3 0.710
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.708
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.708
1drf FOLDihydrofolate reductase 1.5.1.3 0.706
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.706
3drc MTXDihydrofolate reductase 1.5.1.3 0.705
5hi6 MTXDihydrofolate reductase / 0.705
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.704
4dfr MTXDihydrofolate reductase 1.5.1.3 0.704
1re7 FOLDihydrofolate reductase 1.5.1.3 0.702
4p66 MTXDihydrofolate reductase / 0.698
2w3m FOLDihydrofolate reductase 1.5.1.3 0.696
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.692
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.692
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.691
3eig MTXDihydrofolate reductase 1.5.1.3 0.691
3och 2MXDihydrofolate reductase 1.5.1.3 0.691
4qi9 MTXDihydrofolate reductase / 0.691
3dau MTXDihydrofolate reductase 1.5.1.3 0.687
3dfr MTXDihydrofolate reductase 1.5.1.3 0.683
3ia4 MTXDihydrofolate reductase / 0.683
4nhm UN9Prolyl 3,4-dihydroxylase TPA1 1.14.11 0.679
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.678
2dhf DZFDihydrofolate reductase 1.5.1.3 0.678
4p68 MTXDihydrofolate reductase / 0.678
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.673
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.666
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.666
4m6l 21VDihydrofolate reductase 1.5.1.3 0.666
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.663
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.661
3to3 ATPPetrobactin biosynthesis protein AsbB / 0.660
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.658
4fhb FOLDihydrofolate reductase 1.5.1.3 0.658
3frd DHFDihydrofolate reductase 1.5.1.3 0.655
2drc MTXDihydrofolate reductase 1.5.1.3 0.653
1jol FFODihydrofolate reductase 1.5.1.3 0.652
4iqq UMPThymidylate synthase / 0.650