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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rx2 FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1rx2 FOLDihydrofolate reductase 1.5.1.3 1.077
4nx6 FOLDihydrofolate reductase 1.5.1.3 1.001
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.978
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.963
4kjj FOLDihydrofolate reductase 1.5.1.3 0.948
4x5g FOLDihydrofolate reductase 1.5.1.3 0.901
4m6k FOLDihydrofolate reductase 1.5.1.3 0.894
1dyi FOLDihydrofolate reductase 1.5.1.3 0.878
1dyh DZFDihydrofolate reductase 1.5.1.3 0.868
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.865
4x5f FOLDihydrofolate reductase 1.5.1.3 0.863
4fhb FOLDihydrofolate reductase 1.5.1.3 0.860
4i1n FOLDihydrofolate reductase 1.5.1.3 0.860
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.852
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.848
1dyj DDFDihydrofolate reductase 1.5.1.3 0.845
2zza FOLDihydrofolate reductase / 0.845
4i13 FOLDihydrofolate reductase 1.5.1.3 0.844
7dfr FOLDihydrofolate reductase 1.5.1.3 0.844
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.841
4kfj FOLDihydrofolate reductase 1.5.1.3 0.838
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.829
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.827
3frd DHFDihydrofolate reductase 1.5.1.3 0.825
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.822
1re7 FOLDihydrofolate reductase 1.5.1.3 0.820
4x5h FOLDihydrofolate reductase 1.5.1.3 0.815
1jom FFODihydrofolate reductase 1.5.1.3 0.811
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.807
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.804
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.803
3tqb FOLDihydrofolate reductase / 0.795
5ccc DDFDihydrofolate reductase 1.5.1.3 0.795
1dhf FOLDihydrofolate reductase 1.5.1.3 0.788
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.788
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.786
3tq9 MTXDihydrofolate reductase / 0.778
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.776
2w3m FOLDihydrofolate reductase 1.5.1.3 0.775
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.774
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.772
1hfr MOTDihydrofolate reductase 1.5.1.3 0.771
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.771
4x5i FOLDihydrofolate reductase 1.5.1.3 0.767
1dre MTXDihydrofolate reductase 1.5.1.3 0.763
5hi6 MTXDihydrofolate reductase / 0.763
1hfq MOTDihydrofolate reductase 1.5.1.3 0.761
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.758
1drf FOLDihydrofolate reductase 1.5.1.3 0.755
1jol FFODihydrofolate reductase 1.5.1.3 0.751
1dls MTXDihydrofolate reductase 1.5.1.3 0.750
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.748
2d0k FOLDihydrofolate reductase 1.5.1.3 0.745
2drc MTXDihydrofolate reductase 1.5.1.3 0.745
3dau MTXDihydrofolate reductase 1.5.1.3 0.745
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.745
4keb FOLDihydrofolate reductase 1.5.1.3 0.745
1dhj MTXDihydrofolate reductase 1.5.1.3 0.743
3dfr MTXDihydrofolate reductase 1.5.1.3 0.743
3ghw GHWDihydrofolate reductase 1.5.1.3 0.741
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.740
4qi9 MTXDihydrofolate reductase / 0.739
1hfp MOTDihydrofolate reductase 1.5.1.3 0.738
3eig MTXDihydrofolate reductase 1.5.1.3 0.733
1dhi MTXDihydrofolate reductase 1.5.1.3 0.731
1drb MTXDihydrofolate reductase 1.5.1.3 0.731
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.731
1ohj COPDihydrofolate reductase 1.5.1.3 0.730
4p66 MTXDihydrofolate reductase / 0.728
4dfr MTXDihydrofolate reductase 1.5.1.3 0.726
1tdr MTXDihydrofolate reductase 1.5.1.3 0.723
1df7 MTXDihydrofolate reductase 1.5.1.3 0.721
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.719
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.718
4m6l 21VDihydrofolate reductase 1.5.1.3 0.717
3och 2MXDihydrofolate reductase 1.5.1.3 0.715
1dra MTXDihydrofolate reductase 1.5.1.3 0.713
4p68 MTXDihydrofolate reductase / 0.713
2qk8 MTXDihydrofolate reductase / 0.712
3drc MTXDihydrofolate reductase 1.5.1.3 0.711
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.709
1u70 MTXDihydrofolate reductase 1.5.1.3 0.708
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.701
2dhf DZFDihydrofolate reductase 1.5.1.3 0.694
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.688
4x5j FOLDihydrofolate reductase 1.5.1.3 0.677
1e26 GPBDihydrofolate reductase 1.5.1.3 0.670
1daj MOTDihydrofolate reductase 1.5.1.3 0.664
1u72 MTXDihydrofolate reductase 1.5.1.3 0.664
3ghv GHCDihydrofolate reductase 1.5.1.3 0.663
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.661
1u5a BIKL-lactate dehydrogenase 1.1.1.27 0.661
3b1d PLSBetaC-S lyase / 0.659
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.655
2c91 NAPAflatoxin B1 aldehyde reductase member 2 / 0.654
2tpl HPPTyrosine phenol-lyase 4.1.99.2 0.654
3ia4 MTXDihydrofolate reductase / 0.653
1toj HCIAspartate aminotransferase 2.6.1.1 0.652
3kkz SAMUncharacterized protein / 0.650