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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rne C60 Renin 3.4.23.15

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1rne C60Renin 3.4.23.15 1.543
3d91 REMRenin 3.4.23.15 0.886
2g20 L1ARenin 3.4.23.15 0.810
1od1 0QSEndothiapepsin 3.4.23.22 0.807
1bil 0IURenin 3.4.23.15 0.768
2jjj 0QSEndothiapepsin 3.4.23.22 0.764
3dv1 AR9Beta-secretase 1 3.4.23.46 0.764
2g94 ZPQBeta-secretase 1 3.4.23.46 0.761
1e82 M90Endothiapepsin 3.4.23.22 0.756
2jji 0QSEndothiapepsin 3.4.23.22 0.752
1ppm 0P1Penicillopepsin-1 3.4.23.20 0.731
1bxq PP8Penicillopepsin-1 3.4.23.20 0.725
2f3e AXQBeta-secretase 1 3.4.23.46 0.725
3duy AFJBeta-secretase 1 3.4.23.46 0.722
3own 3OWRenin 3.4.23.15 0.717
1e81 M91Endothiapepsin 3.4.23.22 0.709
1zap A70Candidapepsin-2 3.4.23.24 0.708
3dv5 BAVBeta-secretase 1 3.4.23.46 0.706
1ppk IVVPenicillopepsin-1 3.4.23.20 0.700
3k5g BJCBeta-secretase 1 3.4.23.46 0.700
1qrp HH0Pepsin A-4 3.4.23.1 0.698
3veu 0GOBeta-secretase 1 3.4.23.46 0.698
1gvt 2ZSEndothiapepsin 3.4.23.22 0.697
1psa 0ZLPepsin A 3.4.23.1 0.693
1e80 0GQEndothiapepsin 3.4.23.22 0.691
3i25 MV7Beta-secretase 1 3.4.23.46 0.691
1gvw 0EMEndothiapepsin 3.4.23.22 0.690
1eag A70Candidapepsin-2 3.4.23.24 0.689
3own 3OXRenin 3.4.23.15 0.688
4k9h 1QUBeta-secretase 1 3.4.23.46 0.687
2vj7 VG6Beta-secretase 1 3.4.23.46 0.684
2f3f AXFBeta-secretase 1 3.4.23.46 0.682
2qzl IXSBeta-secretase 1 3.4.23.46 0.680
3r2f PB0Beta-secretase 1 3.4.23.46 0.670
3prs RITEndothiapepsin 3.4.23.22 0.668
2web PP4Penicillopepsin-1 3.4.23.20 0.666
3pww ROCEndothiapepsin 3.4.23.22 0.663
3cid 318Beta-secretase 1 3.4.23.46 0.660
1w6h TITPlasmepsin-2 3.4.23.39 0.659
1bai 0Q4Gag-Pro polyprotein / 0.655
1bim 0QBRenin 3.4.23.15 0.655
1me6 IVSPlasmepsin-2 3.4.23.39 0.654
3lpj Z75Beta-secretase 1 3.4.23.46 0.652
1bxo PP7Penicillopepsin-1 3.4.23.20 0.651
2vnm CM8Beta-secretase 1 3.4.23.46 0.650
2wf2 ZY2Beta-secretase 1 3.4.23.46 0.650