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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rh3 MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1rh3 MTXDihydrofolate reductase 1.5.1.3 1.118
1dre MTXDihydrofolate reductase 1.5.1.3 1.047
3dau MTXDihydrofolate reductase 1.5.1.3 0.866
1dra MTXDihydrofolate reductase 1.5.1.3 0.863
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.850
3och 2MXDihydrofolate reductase 1.5.1.3 0.850
2drc MTXDihydrofolate reductase 1.5.1.3 0.846
1u72 MTXDihydrofolate reductase 1.5.1.3 0.845
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.831
3drc MTXDihydrofolate reductase 1.5.1.3 0.831
4dfr MTXDihydrofolate reductase 1.5.1.3 0.829
5hi6 MTXDihydrofolate reductase / 0.825
7dfr FOLDihydrofolate reductase 1.5.1.3 0.823
1df7 MTXDihydrofolate reductase 1.5.1.3 0.822
4p66 MTXDihydrofolate reductase / 0.820
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.816
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.815
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.809
1dls MTXDihydrofolate reductase 1.5.1.3 0.807
3dfr MTXDihydrofolate reductase 1.5.1.3 0.805
1tdr MTXDihydrofolate reductase 1.5.1.3 0.801
3ia4 MTXDihydrofolate reductase / 0.800
4qi9 MTXDihydrofolate reductase / 0.797
1ohj COPDihydrofolate reductase 1.5.1.3 0.791
2qk8 MTXDihydrofolate reductase / 0.787
2zza FOLDihydrofolate reductase / 0.787
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.777
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.774
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.771
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.769
4kjj FOLDihydrofolate reductase 1.5.1.3 0.769
3eig MTXDihydrofolate reductase 1.5.1.3 0.766
1dyj DDFDihydrofolate reductase 1.5.1.3 0.765
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.764
3tq9 MTXDihydrofolate reductase / 0.764
1dyh DZFDihydrofolate reductase 1.5.1.3 0.762
1u70 MTXDihydrofolate reductase 1.5.1.3 0.759
4i1n FOLDihydrofolate reductase 1.5.1.3 0.759
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.752
4x5g FOLDihydrofolate reductase 1.5.1.3 0.752
3dat MTXDihydrofolate reductase / 0.751
1jol FFODihydrofolate reductase 1.5.1.3 0.747
1re7 FOLDihydrofolate reductase 1.5.1.3 0.746
4fhb FOLDihydrofolate reductase 1.5.1.3 0.746
1dhj MTXDihydrofolate reductase 1.5.1.3 0.742
4p68 MTXDihydrofolate reductase / 0.739
4x5f FOLDihydrofolate reductase 1.5.1.3 0.738
1e26 GPBDihydrofolate reductase 1.5.1.3 0.736
1jom FFODihydrofolate reductase 1.5.1.3 0.732
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.730
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.729
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.726
1dyi FOLDihydrofolate reductase 1.5.1.3 0.722
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.722
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.721
2w3m FOLDihydrofolate reductase 1.5.1.3 0.721
4keb FOLDihydrofolate reductase 1.5.1.3 0.721
4m6k FOLDihydrofolate reductase 1.5.1.3 0.721
4x5h FOLDihydrofolate reductase 1.5.1.3 0.721
1hfq MOTDihydrofolate reductase 1.5.1.3 0.720
3frd DHFDihydrofolate reductase 1.5.1.3 0.720
3ghw GHWDihydrofolate reductase 1.5.1.3 0.719
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.716
4kfj FOLDihydrofolate reductase 1.5.1.3 0.713
4i13 FOLDihydrofolate reductase 1.5.1.3 0.712
2dhf DZFDihydrofolate reductase 1.5.1.3 0.711
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.709
1drb MTXDihydrofolate reductase 1.5.1.3 0.703
3ghv GHCDihydrofolate reductase 1.5.1.3 0.703
2d0k FOLDihydrofolate reductase 1.5.1.3 0.701
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.699
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.698
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.697
5ccc DDFDihydrofolate reductase 1.5.1.3 0.697
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.696
1ao8 MTXDihydrofolate reductase 1.5.1.3 0.691
1dhi MTXDihydrofolate reductase 1.5.1.3 0.690
2fzj DH3Dihydrofolate reductase 1.5.1.3 0.689
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.688
3tqb FOLDihydrofolate reductase / 0.688
4x5i FOLDihydrofolate reductase 1.5.1.3 0.686
1drf FOLDihydrofolate reductase 1.5.1.3 0.685
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.678
4m7v RARDihydrofolate reductase / 0.678
1hfp MOTDihydrofolate reductase 1.5.1.3 0.675
1hfr MOTDihydrofolate reductase 1.5.1.3 0.674
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.673
4m6l 21VDihydrofolate reductase 1.5.1.3 0.672
3fra I2HDihydrofolate reductase 1.5.1.3 0.671
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.669
1dhf FOLDihydrofolate reductase 1.5.1.3 0.666
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.664
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.662
1t8x PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.662
1dds MTXDihydrofolate reductase 1.5.1.3 0.657
1ohk COPDihydrofolate reductase 1.5.1.3 0.657
1pd9 CO4Dihydrofolate reductase 1.5.1.3 0.653
1dyr TOPDihydrofolate reductase 1.5.1.3 0.652
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.652