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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rf7 DHF Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1rf7 DHFDihydrofolate reductase 1.5.1.3 1.065
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.915
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.907
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.897
1dyh DZFDihydrofolate reductase 1.5.1.3 0.880
4x5g FOLDihydrofolate reductase 1.5.1.3 0.879
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.865
4kjj FOLDihydrofolate reductase 1.5.1.3 0.864
4i1n FOLDihydrofolate reductase 1.5.1.3 0.863
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.856
1dyi FOLDihydrofolate reductase 1.5.1.3 0.854
4x5f FOLDihydrofolate reductase 1.5.1.3 0.854
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.839
4kfj FOLDihydrofolate reductase 1.5.1.3 0.839
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.838
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.821
7dfr FOLDihydrofolate reductase 1.5.1.3 0.816
4i13 FOLDihydrofolate reductase 1.5.1.3 0.814
4m6k FOLDihydrofolate reductase 1.5.1.3 0.808
1dyj DDFDihydrofolate reductase 1.5.1.3 0.805
4keb FOLDihydrofolate reductase 1.5.1.3 0.801
2zza FOLDihydrofolate reductase / 0.800
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.798
2d0k FOLDihydrofolate reductase 1.5.1.3 0.797
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.795
5ccc DDFDihydrofolate reductase 1.5.1.3 0.792
4x5h FOLDihydrofolate reductase 1.5.1.3 0.791
2w3m FOLDihydrofolate reductase 1.5.1.3 0.787
4fhb FOLDihydrofolate reductase 1.5.1.3 0.785
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.776
1drf FOLDihydrofolate reductase 1.5.1.3 0.774
1re7 FOLDihydrofolate reductase 1.5.1.3 0.773
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.770
1hfq MOTDihydrofolate reductase 1.5.1.3 0.766
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.765
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.763
4x5i FOLDihydrofolate reductase 1.5.1.3 0.763
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.761
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.757
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.757
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.752
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.751
1dhf FOLDihydrofolate reductase 1.5.1.3 0.750
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.749
1hfr MOTDihydrofolate reductase 1.5.1.3 0.747
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.746
1dhi MTXDihydrofolate reductase 1.5.1.3 0.745
4m6l 21VDihydrofolate reductase 1.5.1.3 0.745
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.742
3tq9 MTXDihydrofolate reductase / 0.741
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.739
3drc MTXDihydrofolate reductase 1.5.1.3 0.738
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.737
3ghw GHWDihydrofolate reductase 1.5.1.3 0.731
1dre MTXDihydrofolate reductase 1.5.1.3 0.727
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.727
1df7 MTXDihydrofolate reductase 1.5.1.3 0.722
3dau MTXDihydrofolate reductase 1.5.1.3 0.718
4qi9 MTXDihydrofolate reductase / 0.718
1tdr MTXDihydrofolate reductase 1.5.1.3 0.717
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.715
1hfp MOTDihydrofolate reductase 1.5.1.3 0.713
1drb MTXDihydrofolate reductase 1.5.1.3 0.710
5hi6 MTXDihydrofolate reductase / 0.708
1jom FFODihydrofolate reductase 1.5.1.3 0.702
3och 2MXDihydrofolate reductase 1.5.1.3 0.702
2drc MTXDihydrofolate reductase 1.5.1.3 0.701
1u70 MTXDihydrofolate reductase 1.5.1.3 0.700
1dls MTXDihydrofolate reductase 1.5.1.3 0.699
1e26 GPBDihydrofolate reductase 1.5.1.3 0.698
1u72 MTXDihydrofolate reductase 1.5.1.3 0.697
1ohk COPDihydrofolate reductase 1.5.1.3 0.695
4dfr MTXDihydrofolate reductase 1.5.1.3 0.695
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.695
2fzj DH3Dihydrofolate reductase 1.5.1.3 0.689
4eil FOLBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.683
1ohj COPDihydrofolate reductase 1.5.1.3 0.681
2prh 238Dihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.675
3frd DHFDihydrofolate reductase 1.5.1.3 0.673
1dra MTXDihydrofolate reductase 1.5.1.3 0.672
3dfr MTXDihydrofolate reductase 1.5.1.3 0.672
4p66 MTXDihydrofolate reductase / 0.668
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.667
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.667
2qk8 MTXDihydrofolate reductase / 0.663
1jol FFODihydrofolate reductase 1.5.1.3 0.662
4bqy FNTEgl nine homolog 1 / 0.661
4p68 MTXDihydrofolate reductase / 0.660
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.658
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.657
3aej AA5Methionine gamma-lyase / 0.655
3dat MTXDihydrofolate reductase / 0.655
3fvu IACKynurenine--oxoglutarate transaminase 1 2.6.1.7 0.654
3b1d PLSBetaC-S lyase / 0.650
3zzf NLGProtein ARG5,6, mitochondrial 2.7.2.8 0.650