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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rb2 FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.986
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.822
1dyh DZFDihydrofolate reductase 1.5.1.3 0.815
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.806
1dyi FOLDihydrofolate reductase 1.5.1.3 0.805
4x5f FOLDihydrofolate reductase 1.5.1.3 0.801
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.795
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.793
4x5g FOLDihydrofolate reductase 1.5.1.3 0.767
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.762
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.761
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.759
3tqb FOLDihydrofolate reductase / 0.748
4kjj FOLDihydrofolate reductase 1.5.1.3 0.741
4fhb FOLDihydrofolate reductase 1.5.1.3 0.739
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.731
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.730
1re7 FOLDihydrofolate reductase 1.5.1.3 0.729
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.727
5ccc DDFDihydrofolate reductase 1.5.1.3 0.724
4i13 FOLDihydrofolate reductase 1.5.1.3 0.718
4i1n FOLDihydrofolate reductase 1.5.1.3 0.713
4kfj FOLDihydrofolate reductase 1.5.1.3 0.709
7dfr FOLDihydrofolate reductase 1.5.1.3 0.709
1dyj DDFDihydrofolate reductase 1.5.1.3 0.708
2zza FOLDihydrofolate reductase / 0.704
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.699
4x5h FOLDihydrofolate reductase 1.5.1.3 0.698
4x5i FOLDihydrofolate reductase 1.5.1.3 0.698
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.696
2d0k FOLDihydrofolate reductase 1.5.1.3 0.695
4x5j FOLDihydrofolate reductase 1.5.1.3 0.695
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.691
4m6k FOLDihydrofolate reductase 1.5.1.3 0.687
1dhf FOLDihydrofolate reductase 1.5.1.3 0.682
2w3m FOLDihydrofolate reductase 1.5.1.3 0.679
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.678
1ohj COPDihydrofolate reductase 1.5.1.3 0.678
1drf FOLDihydrofolate reductase 1.5.1.3 0.675
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.671
3ghw GHWDihydrofolate reductase 1.5.1.3 0.670
4qi9 MTXDihydrofolate reductase / 0.664
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.663
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.663
4m6l 21VDihydrofolate reductase 1.5.1.3 0.663
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.657
5hi6 MTXDihydrofolate reductase / 0.656
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.654
1tdr MTXDihydrofolate reductase 1.5.1.3 0.651