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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ra3 MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ra3 MTXDihydrofolate reductase 1.5.1.3 1.024
3drc MTXDihydrofolate reductase 1.5.1.3 0.950
4dfr MTXDihydrofolate reductase 1.5.1.3 0.940
3och 2MXDihydrofolate reductase 1.5.1.3 0.927
5hi6 MTXDihydrofolate reductase / 0.920
1dra MTXDihydrofolate reductase 1.5.1.3 0.919
2drc MTXDihydrofolate reductase 1.5.1.3 0.916
3dau MTXDihydrofolate reductase 1.5.1.3 0.887
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.886
1dhi MTXDihydrofolate reductase 1.5.1.3 0.880
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.880
1df7 MTXDihydrofolate reductase 1.5.1.3 0.872
4p66 MTXDihydrofolate reductase / 0.869
1u70 MTXDihydrofolate reductase 1.5.1.3 0.859
1dhj MTXDihydrofolate reductase 1.5.1.3 0.858
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.858
3eig MTXDihydrofolate reductase 1.5.1.3 0.856
1dls MTXDihydrofolate reductase 1.5.1.3 0.854
1drb MTXDihydrofolate reductase 1.5.1.3 0.854
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.843
1tdr MTXDihydrofolate reductase 1.5.1.3 0.840
3ia4 MTXDihydrofolate reductase / 0.840
3tq9 MTXDihydrofolate reductase / 0.840
4qi9 MTXDihydrofolate reductase / 0.839
1dre MTXDihydrofolate reductase 1.5.1.3 0.833
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.831
1ohj COPDihydrofolate reductase 1.5.1.3 0.810
1u72 MTXDihydrofolate reductase 1.5.1.3 0.810
2qk8 MTXDihydrofolate reductase / 0.796
4x5f FOLDihydrofolate reductase 1.5.1.3 0.795
1hfq MOTDihydrofolate reductase 1.5.1.3 0.793
4x5g FOLDihydrofolate reductase 1.5.1.3 0.789
4m6k FOLDihydrofolate reductase 1.5.1.3 0.785
1jol FFODihydrofolate reductase 1.5.1.3 0.782
1hfr MOTDihydrofolate reductase 1.5.1.3 0.780
4x5h FOLDihydrofolate reductase 1.5.1.3 0.779
2zza FOLDihydrofolate reductase / 0.777
1hfp MOTDihydrofolate reductase 1.5.1.3 0.776
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.776
4kfj FOLDihydrofolate reductase 1.5.1.3 0.772
4kjj FOLDihydrofolate reductase 1.5.1.3 0.767
1dyi FOLDihydrofolate reductase 1.5.1.3 0.766
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.763
3dfr MTXDihydrofolate reductase 1.5.1.3 0.763
5ccc DDFDihydrofolate reductase 1.5.1.3 0.761
1e26 GPBDihydrofolate reductase 1.5.1.3 0.759
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.758
4keb FOLDihydrofolate reductase 1.5.1.3 0.758
3tqb FOLDihydrofolate reductase / 0.756
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.756
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.753
4x5i FOLDihydrofolate reductase 1.5.1.3 0.752
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.751
2w3m FOLDihydrofolate reductase 1.5.1.3 0.749
1re7 FOLDihydrofolate reductase 1.5.1.3 0.742
1dyh DZFDihydrofolate reductase 1.5.1.3 0.741
4i1n FOLDihydrofolate reductase 1.5.1.3 0.741
4p68 MTXDihydrofolate reductase / 0.740
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.739
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.738
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.737
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.737
1jom FFODihydrofolate reductase 1.5.1.3 0.734
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.733
1drf FOLDihydrofolate reductase 1.5.1.3 0.730
7dfr FOLDihydrofolate reductase 1.5.1.3 0.729
4i13 FOLDihydrofolate reductase 1.5.1.3 0.728
1dds MTXDihydrofolate reductase 1.5.1.3 0.726
1dhf FOLDihydrofolate reductase 1.5.1.3 0.726
2d0k FOLDihydrofolate reductase 1.5.1.3 0.724
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.722
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.719
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.718
3dat MTXDihydrofolate reductase / 0.714
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.714
3td8 D2RDihydrofolate reductase 1.5.1.3 0.712
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.712
1ddr MTXDihydrofolate reductase 1.5.1.3 0.711
3ghw GHWDihydrofolate reductase 1.5.1.3 0.711
2dhf DZFDihydrofolate reductase 1.5.1.3 0.710
1ohk COPDihydrofolate reductase 1.5.1.3 0.708
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.708
1dyj DDFDihydrofolate reductase 1.5.1.3 0.707
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.705
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.702
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.695
3frd DHFDihydrofolate reductase 1.5.1.3 0.692
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.690
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.689
4m6l 21VDihydrofolate reductase 1.5.1.3 0.687
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.685
4fhb FOLDihydrofolate reductase 1.5.1.3 0.682
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.677
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.673
3jw3 TOPDihydrofolate reductase / 0.671
3jw5 TOPDihydrofolate reductase / 0.671
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.668
4bqy FNTEgl nine homolog 1 / 0.665
3ghv GHCDihydrofolate reductase 1.5.1.3 0.659
4ixf IXFDihydrofolate reductase 1.5.1.3 0.655
1w06 W05Isopenicillin N synthase 1.21.3.1 0.651
1obn ASVIsopenicillin N synthase 1.21.3.1 0.650
1qiq ACCIsopenicillin N synthase 1.21.3.1 0.650
4ajo 88NL-lactate dehydrogenase A chain 1.1.1.27 0.650