Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ra2 FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.978
4x5f FOLDihydrofolate reductase 1.5.1.3 0.899
4x5g FOLDihydrofolate reductase 1.5.1.3 0.899
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.895
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.894
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.893
4kjj FOLDihydrofolate reductase 1.5.1.3 0.892
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.882
1dyh DZFDihydrofolate reductase 1.5.1.3 0.878
1dyi FOLDihydrofolate reductase 1.5.1.3 0.873
7dfr FOLDihydrofolate reductase 1.5.1.3 0.848
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.841
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.838
3tqb FOLDihydrofolate reductase / 0.837
4fhb FOLDihydrofolate reductase 1.5.1.3 0.831
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.821
2zza FOLDihydrofolate reductase / 0.812
4m6k FOLDihydrofolate reductase 1.5.1.3 0.811
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.802
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.798
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.794
4x5h FOLDihydrofolate reductase 1.5.1.3 0.791
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.790
4kfj FOLDihydrofolate reductase 1.5.1.3 0.789
1dyj DDFDihydrofolate reductase 1.5.1.3 0.787
4i1n FOLDihydrofolate reductase 1.5.1.3 0.787
5ccc DDFDihydrofolate reductase 1.5.1.3 0.783
4keb FOLDihydrofolate reductase 1.5.1.3 0.781
4i13 FOLDihydrofolate reductase 1.5.1.3 0.780
1dhf FOLDihydrofolate reductase 1.5.1.3 0.774
1hfr MOTDihydrofolate reductase 1.5.1.3 0.773
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.773
3tq9 MTXDihydrofolate reductase / 0.765
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.763
4m6l 21VDihydrofolate reductase 1.5.1.3 0.763
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.762
1drf FOLDihydrofolate reductase 1.5.1.3 0.761
2d0k FOLDihydrofolate reductase 1.5.1.3 0.761
4x5i FOLDihydrofolate reductase 1.5.1.3 0.760
1dhj MTXDihydrofolate reductase 1.5.1.3 0.754
2w3m FOLDihydrofolate reductase 1.5.1.3 0.751
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.749
4p66 MTXDihydrofolate reductase / 0.747
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.745
4qi9 MTXDihydrofolate reductase / 0.742
1tdr MTXDihydrofolate reductase 1.5.1.3 0.741
2drc MTXDihydrofolate reductase 1.5.1.3 0.740
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.739
1dre MTXDihydrofolate reductase 1.5.1.3 0.736
1hfq MOTDihydrofolate reductase 1.5.1.3 0.735
1e26 GPBDihydrofolate reductase 1.5.1.3 0.732
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.732
5hi6 MTXDihydrofolate reductase / 0.732
1hfp MOTDihydrofolate reductase 1.5.1.3 0.731
3eig MTXDihydrofolate reductase 1.5.1.3 0.731
3dfr MTXDihydrofolate reductase 1.5.1.3 0.728
3drc MTXDihydrofolate reductase 1.5.1.3 0.728
1re7 FOLDihydrofolate reductase 1.5.1.3 0.726
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.726
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.726
3ghw GHWDihydrofolate reductase 1.5.1.3 0.722
3och 2MXDihydrofolate reductase 1.5.1.3 0.720
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.717
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.715
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.715
1dra MTXDihydrofolate reductase 1.5.1.3 0.713
1drb MTXDihydrofolate reductase 1.5.1.3 0.710
1dhi MTXDihydrofolate reductase 1.5.1.3 0.708
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.708
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.707
4p68 MTXDihydrofolate reductase / 0.702
1dls MTXDihydrofolate reductase 1.5.1.3 0.701
4dfr MTXDihydrofolate reductase 1.5.1.3 0.701
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.701
3dau MTXDihydrofolate reductase 1.5.1.3 0.700
1df7 MTXDihydrofolate reductase 1.5.1.3 0.699
1u70 MTXDihydrofolate reductase 1.5.1.3 0.694
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.686
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.685
3frd DHFDihydrofolate reductase 1.5.1.3 0.682
3ia4 MTXDihydrofolate reductase / 0.671
1ohj COPDihydrofolate reductase 1.5.1.3 0.669
2dhf DZFDihydrofolate reductase 1.5.1.3 0.666
3ghv GHCDihydrofolate reductase 1.5.1.3 0.666
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.666
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.665
1jol FFODihydrofolate reductase 1.5.1.3 0.661
1jom FFODihydrofolate reductase 1.5.1.3 0.653
5li5 THR_ALA_ASN_PRO_SEPKLTH0G14146p / 0.653
4to3 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.651