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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1r1i TI1 Neprilysin

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1r1i TI1Neprilysin / 1.051
1r1j OIRNeprilysin / 0.790
1u4g HPIElastase 3.4.24.26 0.695
3t74 UBYThermolysin 3.4.24.27 0.690
3t8c UBWThermolysin 3.4.24.27 0.676
3t87 UBZThermolysin 3.4.24.27 0.675
3t8h UBSThermolysin 3.4.24.27 0.675
4tmn 0PKThermolysin 3.4.24.27 0.673
4cth RDFNeprilysin / 0.672
3dwb RDFEndothelin-converting enzyme 1 3.4.24.71 0.667
3t8d UBVThermolysin 3.4.24.27 0.667
4d9w X32Thermolysin 3.4.24.27 0.667
4h57 0PJThermolysin 3.4.24.27 0.667
3fv4 1U4Thermolysin 3.4.24.27 0.658
6tmn 0PIThermolysin 3.4.24.27 0.658
3zuk RDFEndopeptidase, peptidase family M13 / 0.651