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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1qzf FOL Bifunctional dihydrofolate reductase-thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.885
4m6k FOLDihydrofolate reductase 1.5.1.3 0.741
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.735
4i13 FOLDihydrofolate reductase 1.5.1.3 0.725
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.719
4kfj FOLDihydrofolate reductase 1.5.1.3 0.718
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.717
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.715
2w3m FOLDihydrofolate reductase 1.5.1.3 0.712
4keb FOLDihydrofolate reductase 1.5.1.3 0.711
4kjj FOLDihydrofolate reductase 1.5.1.3 0.711
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.705
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.705
3dfr MTXDihydrofolate reductase 1.5.1.3 0.699
1dhf FOLDihydrofolate reductase 1.5.1.3 0.698
2dhf DZFDihydrofolate reductase 1.5.1.3 0.694
1hfr MOTDihydrofolate reductase 1.5.1.3 0.686
1u4s BIHL-lactate dehydrogenase 1.1.1.27 0.686
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.686
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.685
3ia4 MTXDihydrofolate reductase / 0.685
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.682
2zza FOLDihydrofolate reductase / 0.681
3ghw GHWDihydrofolate reductase 1.5.1.3 0.676
5hi6 MTXDihydrofolate reductase / 0.676
4m6l 21VDihydrofolate reductase 1.5.1.3 0.674
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.674
1dyh DZFDihydrofolate reductase 1.5.1.3 0.673
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.673
2d0k FOLDihydrofolate reductase 1.5.1.3 0.673
1hfp MOTDihydrofolate reductase 1.5.1.3 0.671
1hfq MOTDihydrofolate reductase 1.5.1.3 0.671
3td8 D2RDihydrofolate reductase 1.5.1.3 0.670
4x5f FOLDihydrofolate reductase 1.5.1.3 0.669
1u72 MTXDihydrofolate reductase 1.5.1.3 0.668
4fhb FOLDihydrofolate reductase 1.5.1.3 0.668
1dls MTXDihydrofolate reductase 1.5.1.3 0.666
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.666
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.665
1ohk COPDihydrofolate reductase 1.5.1.3 0.664
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.662
5ccc DDFDihydrofolate reductase 1.5.1.3 0.661
2ahc VNLChorismate pyruvate-lyase / 0.659
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.659
4nhm UN9Prolyl 3,4-dihydroxylase TPA1 1.14.11 0.658
1dyj DDFDihydrofolate reductase 1.5.1.3 0.657
1re7 FOLDihydrofolate reductase 1.5.1.3 0.657
1drf FOLDihydrofolate reductase 1.5.1.3 0.656
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.656
2bjs ACVIsopenicillin N synthase 1.21.3.1 0.656
1df7 MTXDihydrofolate reductase 1.5.1.3 0.655
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.655
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.655
4x5h FOLDihydrofolate reductase 1.5.1.3 0.655
4kyh ZSTLactoylglutathione lyase 4.4.1.5 0.654
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.654
1u70 MTXDihydrofolate reductase 1.5.1.3 0.653
1qiq ACCIsopenicillin N synthase 1.21.3.1 0.652
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.652
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.652
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.651
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.650
3zky WT4Isopenicillin N synthase 1.21.3.1 0.650