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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1qsm ACO Histone acetyltransferase HPA2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1qsm ACOHistone acetyltransferase HPA2 / 1.336
3pgp ACOUncharacterized protein / 0.865
2vez ACOGlucosamine 6-phosphate acetyltransferase, putative / 0.854
4kub COAUncharacterized protein / 0.846
1i12 ACOGlucosamine 6-phosphate N-acetyltransferase / 0.843
1bob ACOHistone acetyltransferase type B catalytic subunit / 0.836
2jdd ACOProbable acetyltransferase / 0.802
1ghe ACOAcetyltransferase 2.3.1 0.797
2bei ACODiamine acetyltransferase 2 2.3.1.57 0.796
1cjw COTSerotonin N-acetyltransferase / 0.783
2a4n COAAac(6')-Ii protein / 0.777
2x7b COAN-alpha-acetyltransferase 2.3.1 0.767
2fxf ACODiamine acetyltransferase 1 / 0.766
4lx9 ACON-alpha-acetyltransferase 2.3.1 0.765
4ag7 COAGlucosamine 6-phosphate N-acetyltransferase / 0.764
1ib1 COTSerotonin N-acetyltransferase / 0.763
3s6f COAUncharacterized protein / 0.762
2r8v ACOAmino-acid acetyltransferase / 0.761
3te4 ACODopamine N-acetyltransferase / 0.761
2cy2 ACOProbable acetyltransferase / 0.760
2ge3 ACOProbable acetyltransferase / 0.760
2q4v ACODiamine acetyltransferase 2 2.3.1.57 0.758
1kuv CA5Serotonin N-acetyltransferase / 0.757
2rc4 ACOHistone acetyltransferase KAT6A / 0.755
1ozp ACOMycothiol acetyltransferase 2.3.1.189 0.752
1tiq COASpermidine/spermine N(1)-acetyltransferase / 0.751
2b3v ACODiamine acetyltransferase 1 / 0.748
2fiw ACOGCN5-related N-acetyltransferase:Aminotransferase, class-II / 0.739
4qvt ACOAcetyltransferase YpeA 2.3.1 0.737
1n71 COAAac(6')-Ii protein / 0.736
3d2m COAAmino-acid acetyltransferase / 0.736
3f8k COAUncharacterized protein / 0.736
4mxe ACON-acetyltransferase ESCO1 2.3.1 0.735
1l0c COTSerotonin N-acetyltransferase / 0.731
4ava ACOAcetyltransferase Pat 2.3.1 0.731
2bsw CAOProbable acetyltransferase / 0.728
5h84 1VUHistone acetyltransferase KAT2A 2.3.1.48 0.727
1qsr ACOHAT A1 / 0.724
2jdc CAOProbable acetyltransferase / 0.722
4r87 COASpermidine N(1)-acetyltransferase / 0.722
1cm0 COAHistone acetyltransferase KAT2B 2.3.1.48 0.721
1s3z COAAminoglycoside N(6')-acetyltransferase type 1 / 0.720
2cns ACORibosomal-protein-alanine acetyltransferase / 0.720
1p0h COAMycothiol acetyltransferase 2.3.1.189 0.715
4ri1 ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase 2.3.1.202 0.715
5kf8 ACOPredicted acetyltransferase / 0.715
1b87 ACOAac(6')-Ii protein / 0.714
5kf9 ACOPredicted acetyltransferase / 0.714
5kf2 COAPredicted acetyltransferase / 0.711
1mja COAHistone acetyltransferase ESA1 / 0.710
5kf1 ACOPredicted acetyltransferase / 0.710
4r3k COAN-alpha-acetyltransferase 2.3.1 0.709
2vbq BSJAminoglycoside N(6')-acetyltransferase type 1 / 0.708
4hkf ACOAlpha-tubulin N-acetyltransferase 1 / 0.708
2b58 COADiamine acetyltransferase 1 / 0.705
1kuy COTSerotonin N-acetyltransferase / 0.704
1m4i COAAminoglycoside 2'-N-acetyltransferase 2.3.1 0.702
5kf8 COAPredicted acetyltransferase / 0.701
1j4j ACOAcetyltransferase 2.3.1 0.699
4psw COAHistone acetyltransferase type B catalytic subunit / 0.699
5h86 BCOHistone acetyltransferase KAT2A 2.3.1.48 0.698
3k9u ACOSpermidine N(1)-acetyltransferase / 0.696
2cnt COARibosomal-protein-alanine acetyltransferase / 0.695
5kgj ACOPredicted acetyltransferase / 0.694
4kvx ACON-terminal acetyltransferase A complex catalytic subunit ard1 2.3.1.88 0.692
4jwp ACOGCN5-related N-acetyltransferase / 0.691
3exn ACOProbable acetyltransferase / 0.690
1p0h ACOMycothiol acetyltransferase 2.3.1.189 0.687
4xnh ACON-terminal acetyltransferase A complex subunit NAT5 2.3.1 0.687
5kgp ACOPredicted acetyltransferase / 0.687
3dr8 ACOL-methionine sulfoximine/L-methionine sulfone acetyltransferase / 0.686
5kf2 ACOPredicted acetyltransferase / 0.686
4u9v ACON-alpha-acetyltransferase 40 2.3.1 0.680
5kgh ACOPredicted acetyltransferase / 0.680
1pu9 COAHAT A1 / 0.679
2y0m ACOHistone acetyltransferase KAT8 / 0.678
1kux CA3Serotonin N-acetyltransferase / 0.677
3mgd ACOPredicted acetyltransferase / 0.676
3zj0 ACOPutative acetyltransferase OgpAT / 0.676
4b5p ACOAlpha-tubulin N-acetyltransferase 1 / 0.675
5ag7 MYAGlycylpeptide N-tetradecanoyltransferase / 0.674
3vwd ACOAlpha-tubulin N-acetyltransferase 1 / 0.672
3f0a ACOSpermidine N(1)-acetyltransferase / 0.671
4u9z COAAlpha-tubulin N-acetyltransferase 1 / 0.671
2o28 COAGlucosamine 6-phosphate N-acetyltransferase / 0.670
2vxk COAGlucosamine 6-phosphate acetyltransferase, putative / 0.670
4zm6 ACON-acetyl-beta-D glucosaminidase / 0.670
1z4r ACOHistone acetyltransferase KAT2A 2.3.1.48 0.666
1s7n COAAcetyl transferase / 0.665
2qir COAAminoglycoside 6-N-acetyltransferase type Ib11 / 0.664
1qsn COAHAT A1 / 0.662
2bue COAAAC(6')-Ib / 0.660
3d2p COAAmino-acid acetyltransferase / 0.660
4ua3 COAN-alpha-acetyltransferase 40 2.3.1 0.660
4jxr ACOAcetyltransferase / 0.659
1wwz ACOUncharacterized protein / 0.658
3vwe COAAlpha-tubulin N-acetyltransferase 1 / 0.658
3bj7 COADiamine acetyltransferase 1 / 0.657
4xpd ACON-terminal acetyltransferase A complex subunit NAT5 2.3.1 0.657
1bo4 COAAminoglycoside-(3)-N-acetyltransferase / 0.653
2zpa ACOtRNA(Met) cytidine acetyltransferase TmcA / 0.651
2zw5 COABleomycin acetyltransferase / 0.651
5c88 COAN-alpha-acetyltransferase / 0.651