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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1qpe PP2 Tyrosine-protein kinase Lck 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1qpe PP2Tyrosine-protein kinase Lck 2.7.10.2 0.928
1yol S03Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.773
2zv9 PP2Tyrosine-protein kinase Lyn 2.7.10.2 0.771
4e5i 0N9Polymerase acidic protein / 0.744
2c0t L3GTyrosine-protein kinase HCK 2.7.10.2 0.721
2ivv PP1Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.720
2c0i L1GTyrosine-protein kinase HCK 2.7.10.2 0.712
4mxo DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.711
3vs5 VSGTyrosine-protein kinase HCK 2.7.10.2 0.709
3vs0 VS0Tyrosine-protein kinase HCK 2.7.10.2 0.702
5f0a 1FBcGMP-dependent protein kinase, putative / 0.696
3vs3 VSETyrosine-protein kinase HCK 2.7.10.2 0.689
4lgg VGGProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.688
4gu9 4GUFocal adhesion kinase 1 2.7.10.2 0.680
5hes 032Mitogen-activated protein kinase kinase kinase 20 2.7.11.25 0.680
3vs1 VSATyrosine-protein kinase HCK 2.7.10.2 0.678
3vs7 KS1Tyrosine-protein kinase HCK 2.7.10.2 0.676
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.667
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.665
3vs4 VSFTyrosine-protein kinase HCK 2.7.10.2 0.664
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.661
2zva 1N1Tyrosine-protein kinase Lyn 2.7.10.2 0.660
3vry B43Tyrosine-protein kinase HCK 2.7.10.2 0.660
4xey 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.660
2c0o L2GTyrosine-protein kinase HCK 2.7.10.2 0.657