Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1pzg A3D Lactate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1pzg A3DLactate dehydrogenase / 1.090
1pzh NADLactate dehydrogenase / 1.023
1t2d NADL-lactate dehydrogenase 1.1.1.27 1.015
1sow NADL-lactate dehydrogenase 1.1.1.27 0.999
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.977
1pzf A3DLactate dehydrogenase / 0.972
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.936
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.905
2aa3 AP0L-lactate dehydrogenase / 0.897
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.866
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.864
4ros APRMalate dehydrogenase / 0.850
2a92 NAIL-lactate dehydrogenase / 0.843
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.815
4i1i NADMalate dehydrogenase / 0.780
1gv0 NADMalate dehydrogenase / 0.774
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.753
2x0i NAIMalate dehydrogenase / 0.753
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.751
4j43 NADUncharacterized protein / 0.743
1ib6 NADMalate dehydrogenase / 0.742
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.741
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.741
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.741
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.740
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.740
1b8v NADMalate dehydrogenase / 0.735
1u7h NADPutative ornithine cyclodeaminase / 0.734
1wze NADMalate dehydrogenase / 0.732
1bdm NAXMalate dehydrogenase / 0.730
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.730
1bmd NADMalate dehydrogenase / 0.729
1y7t NDPMalate dehydrogenase / 0.729
1uxk NADMalate dehydrogenase / 0.724
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.723
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.720
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.717
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.711
1b8u NADMalate dehydrogenase / 0.709
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.708
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.708
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.707
4j4b NAIUncharacterized protein / 0.706
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.702
1uxj NADMalate dehydrogenase / 0.700
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.700
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.700
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.698
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.697
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.697
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.697
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.696
2x0r NADMalate dehydrogenase / 0.695
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.694
3gvh NADMalate dehydrogenase / 0.693
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.691
4cr8 NADN-acylmannosamine 1-dehydrogenase 1.1.1.233 0.691
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.688
1wzi NDPMalate dehydrogenase / 0.688
1ie3 NADMalate dehydrogenase / 0.687
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.686
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.684
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.684
2o4c NADErythronate-4-phosphate dehydrogenase / 0.684
4oaq NDPR-specific carbonyl reductase / 0.683
2p9g NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.682
4lis NADUDP-glucose 4-epimerase (Eurofung) / 0.682
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.681
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.681
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.681
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.678
1up7 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.677
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.677
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.676
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.676
3gvi ADPMalate dehydrogenase / 0.676
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.676
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.675
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.675
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.673
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.672
1c1d NAIPhenylalanine dehydrogenase / 0.670
2wdz NADGalactitol dehydrogenase / 0.669
1h2h NADL-aspartate dehydrogenase 1.4.1.21 0.667
1o6z NADMalate dehydrogenase / 0.667
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.667
2xaa NADSecondary alcohol dehydrogenase / 0.667
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.666
2voj NADAlanine dehydrogenase 1.4.1.1 0.666
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.665
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.664
3jv7 NADSecondary alcohol dehydrogenase / 0.664
3rfx NADUronate dehydrogenase / 0.664
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.664
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.663
2hjr APRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase / 0.662
3geg NADShort-chain dehydrogenase/reductase SDR / 0.661
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.661
3wmx NADNAD dependent epimerase/dehydratase / 0.660
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.660
2p5y NADUDP-glucose 4-epimerase / 0.659
3ggp NADPrephenate dehydrogenase / 0.659
3wle NAD(R)-specific carbonyl reductase / 0.658
4pvd NDPNADPH-dependent methylglyoxal reductase GRE2 / 0.658
3fvq ATPFe(3+) ions import ATP-binding protein FbpC / 0.657
4cpd NADAlcohol dehydrogenase / 0.657
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.657
3d64 NADAdenosylhomocysteinase / 0.656
1f8f NADBenzyl alcohol dehydrogenase / 0.655
1yqd NAPSinapyl alcohol dehydrogenase / 0.655
3lu1 NADUDP-N-acetylglucosamine 4-epimerase / 0.655
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.655
2wsb NADGalactitol dehydrogenase / 0.654
3nx4 NAPPutative oxidoreductase / 0.653
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.653
2c20 NADUDP-glucose 4-epimerase / 0.651
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.651
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.650
4k28 NADShikimate dehydrogenase family protein / 0.650