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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1pkg ADP Mast/stem cell growth factor receptor Kit 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.925
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.735
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.734
4ysj ADPCalmodulin-like domain protein kinase / 0.727
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.718
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.709
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.706
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.704
5dos ATPAurora kinase A 2.7.11.1 0.704
4c3p ACPAurora kinase A 2.7.11.1 0.700
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.696
3pff ADPATP-citrate synthase 2.3.3.8 0.694
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.693
4qny ANPMitogen activated protein kinase, putative / 0.690
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.686
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.686
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.684
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.681
5dnr ATPAurora kinase A 2.7.11.1 0.680
3c4z ADPRhodopsin kinase / 0.679
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.676
5dt4 ATPAurora kinase A 2.7.11.1 0.676
1ny3 ADPMAP kinase-activated protein kinase 2 2.7.11.1 0.675
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.675
4c3r ACPAurora kinase A 2.7.11.1 0.675
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.674
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.673
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.673
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.671
2pzp ACPFibroblast growth factor receptor 2 / 0.671
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.671
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.671
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.670
3bu5 ATPInsulin receptor 2.7.10.1 0.669
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.669
2dwb ANPAurora kinase A 2.7.11.1 0.668
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.667
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.665
5drd ATPAurora kinase A 2.7.11.1 0.665
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.664
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.664
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.662
3orm AGSSerine/threonine protein kinase / 0.662
5l8l ADPAurora kinase A 2.7.11.1 0.661
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.659
2pui ADPMethylthioribose kinase 2.7.1.100 0.658
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.657
4to4 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.656
4xlv ACPInsulin receptor 2.7.10.1 0.656
4lv8 ADPRhoptry protein 5 C / 0.655
4n57 ADPAPH(2'')-Id / 0.655
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.654
2pyw ADPMethylthioribose kinase 2.7.1.100 0.654
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.654
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.654
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.653
4gyi ADPUncharacterized protein / 0.653
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.653
4hne ADPPhosphatidylinositol 4-kinase type 2-alpha / 0.652
4to3 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.652
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.651
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.651
5l8k ADPAurora kinase A 2.7.11.1 0.651