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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1pkd UCN Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.964
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.853
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.809
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.809
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.805
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.770
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.769
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.769
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.764
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.761
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.755
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.754
1xjd STUProtein kinase C theta type 2.7.11.13 0.754
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.752
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.751
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.743
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.741
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.737
1byg STUTyrosine-protein kinase CSK / 0.733
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.728
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.725
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.724
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.723
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.723
1x8b 824Wee1-like protein kinase 2.7.10.2 0.720
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.720
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.719
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.713
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.710
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.707
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.707
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.706
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.703
4bid IE8Mitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.703
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.701
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.700
3zew STUEphrin type-B receptor 4 2.7.10.1 0.695
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.690
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.690
1wvy STUDeath-associated protein kinase 1 2.7.11.1 0.685
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.684
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.674
2z2w 770Wee1-like protein kinase 2.7.10.2 0.673
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.672
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.667
2j0k 4STFocal adhesion kinase 1 2.7.10.2 0.665
1ke6 LS2Cyclin-dependent kinase 2 2.7.11.22 0.662
3bi6 396Wee1-like protein kinase 2.7.10.2 0.662
3f69 XDRSerine/threonine-protein kinase PknB 2.7.11.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
2bhe BRYCyclin-dependent kinase 2 2.7.11.22 0.653
3rk7 08ZCyclin-dependent kinase 2 2.7.11.22 0.652