Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1phk ATP Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 1.121
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.960
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.955
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.930
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.927
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.921
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.919
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.915
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.915
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.908
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.905
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.879
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.877
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.874
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.868
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.862
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.862
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.859
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.852
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.851
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.846
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.845
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.844
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.837
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.828
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.826
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.819
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.819
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.817
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.810
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.810
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.807
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.807
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.806
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.798
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.794
1mq4 ADPAurora kinase A 2.7.11.1 0.793
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.788
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.788
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.784
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.783
5dr2 ATPAurora kinase A 2.7.11.1 0.783
5dn3 ATPAurora kinase A 2.7.11.1 0.781
2pui ADPMethylthioribose kinase 2.7.1.100 0.778
4qny ANPMitogen activated protein kinase, putative / 0.778
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.776
4utd ACPAurora kinase A 2.7.11.1 0.776
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.775
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.775
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.772
4dee ADPAurora kinase A 2.7.11.1 0.770
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.770
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.769
2pml ANPUncharacterized protein / 0.768
4ysj ADPCalmodulin-like domain protein kinase / 0.768
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.767
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.766
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.764
2pul ACPMethylthioribose kinase 2.7.1.100 0.763
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.763
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.762
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.761
5ce3 ADPProtein kinase YopO / 0.759
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.757
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.756
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.755
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.754
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.752
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.751
3cly ACPFibroblast growth factor receptor 2 / 0.751
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.750
2pup ADPMethylthioribose kinase 2.7.1.100 0.749
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.749
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.748
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.744
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.743
2pz5 ACPFibroblast growth factor receptor 2 / 0.743
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.742
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.742
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.742
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.742
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.740
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.739
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.739
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.738
4bn1 ADPAurora kinase A 2.7.11.1 0.738
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.736
4ceg ADPAurora kinase A 2.7.11.1 0.735
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.734
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.734
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.734
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.734
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.732
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.731
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.731
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.730
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.730
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.729
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.727
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.727
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.727
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.727
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.726
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.726
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.724
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.724
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.724
4o4d ATPKinase / 0.724
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.724
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.723
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.723
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.723
4gyi ADPUncharacterized protein / 0.723
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.722
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.722
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.721
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.721
4ork GDPBifunctional AAC/APH 2.3.1 0.721
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.720
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.719
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.717
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.717
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.717
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.717
4xlv ACPInsulin receptor 2.7.10.1 0.717
3rv4 ADPBiotin carboxylase 6.3.4.14 0.716
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.716
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.716
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.716
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.715
3t8o ATPRhodopsin kinase / 0.715
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.714
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
1m0w ANPGlutathione synthetase 6.3.2.3 0.710
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.710
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.710
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.709
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.709
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.709
5dt4 ATPAurora kinase A 2.7.11.1 0.709
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.708
5dos ATPAurora kinase A 2.7.11.1 0.708
2dwb ANPAurora kinase A 2.7.11.1 0.707
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.707
3qc9 ADPRhodopsin kinase / 0.707
2py3 ACPFibroblast growth factor receptor 2 / 0.706
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.706
5iqa GNPBifunctional AAC/APH 2.3.1 0.706
3bu5 ATPInsulin receptor 2.7.10.1 0.705
1u54 ACPActivated CDC42 kinase 1 / 0.703
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.703
5eg3 ACPFibroblast growth factor receptor 2 / 0.703
5iqe GNPBifunctional AAC/APH 2.3.1 0.703
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.702
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.702
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.701
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.701
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.701
3nie ANPMitogen-activated protein kinase / 0.700
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.699
3c4z ADPRhodopsin kinase / 0.698
3tdw GDPGentamicin resistance protein / 0.698
5dnr ATPAurora kinase A 2.7.11.1 0.697
3orm AGSSerine/threonine protein kinase / 0.695
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.695
3c50 ADPRhodopsin kinase / 0.694
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.694
2pzp ACPFibroblast growth factor receptor 2 / 0.693
3lmi ATPMyosin heavy chain kinase A 2.7.11.7 0.693
3g8c ADPBiotin carboxylase 6.3.4.14 0.692
2pun ACPMethylthioribose kinase 2.7.1.100 0.691
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.691
5dt3 ATPAurora kinase A 2.7.11.1 0.691
1dv2 ATPBiotin carboxylase 6.3.4.14 0.690
5iqb GNPBifunctional AAC/APH 2.3.1 0.690
2vqd AP2Biotin carboxylase 6.3.4.14 0.689
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.688
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.687
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.686
2pyw ADPMethylthioribose kinase 2.7.1.100 0.686
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.685
5iqf GDPBifunctional AAC/APH 2.3.1 0.685
3a8w ATPProtein kinase C iota type 2.7.11.13 0.684
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.684
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.684
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.683
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.682
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.682
3tdv GDPGentamicin resistance protein / 0.681
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.681
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.679
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.679
2j9g ADPBiotin carboxylase 6.3.4.14 0.679
3c4w ATPRhodopsin kinase / 0.679
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.679
2vo0 M03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.678
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.677
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.675
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.674
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.674
4ffl ADPUncharacterized protein / 0.674
4xx9 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.674
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.673
2x86 ADPADP-L-glycero-D-manno-heptose-6-epimerase / 0.673
4ffr ATPUncharacterized protein / 0.673
4kln AGSTransitional endoplasmic reticulum ATPase 3.6.4.6 0.673
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.673
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.672
3umo ATPATP-dependent 6-phosphofructokinase isozyme 2 2.7.1.11 0.672
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
2zoq 5IDMitogen-activated protein kinase 3 2.7.11.24 0.671
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.670
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.670
3ori AGSSerine/threonine protein kinase / 0.670
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.670
5iqh GNPBifunctional AAC/APH 2.3.1 0.669
1ir3 ANPInsulin receptor 2.7.10.1 0.668
3wnz ADPAlanine--anticapsin ligase / 0.668
3t54 ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.667
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.666
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.666
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.666
4o1p ANPRibonuclease L / 0.666
1fq1 ATPCyclin-dependent kinase 2 2.7.11.22 0.664
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.664
5l6w AGSLIM domain kinase 1 2.7.11.1 0.664
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.663
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.661
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.661
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.661
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.661
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.660
2zdg ADPD-alanine--D-alanine ligase / 0.660
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.660
3zo1 SIJcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4bix ADPSensor histidine kinase CpxA / 0.660
5drd ATPAurora kinase A 2.7.11.1 0.660
1cm8 ANPMitogen-activated protein kinase 12 / 0.659
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.659
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.658
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.658
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.657
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.657
5byl GCPBifunctional AAC/APH 2.3.1 0.657
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.656
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.656
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.656
4xeo A5AAlanine--tRNA ligase, cytoplasmic / 0.656
4rqv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.654
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.653
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.652
3c4x ATPRhodopsin kinase / 0.652
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.651
3orl AGSSerine/threonine protein kinase / 0.651
3wo0 ADPAlanine--anticapsin ligase / 0.651
4c3p ACPAurora kinase A 2.7.11.1 0.651
4o4e ATPKinase / 0.651
4zgn ATPCell division cycle protein 123 / 0.651
1e79 ADPATP synthase subunit alpha, mitochondrial / 0.650
1e79 ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.650
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.650
2o8b ADPDNA mismatch repair protein Msh2 / 0.650
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.650
4n57 ADPAPH(2'')-Id / 0.650
4wh3 ATPN-acetylhexosamine 1-kinase 2.7.1.162 0.650