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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1p2a 5BN Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1p2a 5BNCyclin-dependent kinase 2 2.7.11.22 1.051
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.802
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.775
1ke8 LS4Cyclin-dependent kinase 2 2.7.11.22 0.769
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.764
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.760
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.757
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1ke9 LS5Cyclin-dependent kinase 2 2.7.11.22 0.743
3l9l L9LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.718
3py0 SU9Cyclin-dependent kinase 2 2.7.11.22 0.718
3eb0 DRKUncharacterized protein / 0.713
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.701
1fvv 107Cyclin-dependent kinase 2 2.7.11.22 0.691
3vqh IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
2jdv L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
3hzt J60Calmodulin-like domain protein kinase isoform 3 / 0.682
2uzt SS3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
1gih 1PUCyclin-dependent kinase 2 2.7.11.22 0.677
3g0e B49Mast/stem cell growth factor receptor Kit 2.7.10.1 0.675
3l9m L9McAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
2f7e 2EAcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
2jds L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
4j71 1JXGlycogen synthase kinase-3 beta 2.7.11.26 0.673
2jam J60Calcium/calmodulin-dependent protein kinase type 1G 2.7.11.17 0.672
2gnl H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
3qrt X14Cyclin-dependent kinase 2 2.7.11.22 0.669
3qql X03Cyclin-dependent kinase 2 2.7.11.22 0.668
2uzu L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
2uzw SS4cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 0.667
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.666
2vth LZ2Cyclin-dependent kinase 2 2.7.11.22 0.666
3g0f B49Mast/stem cell growth factor receptor Kit 2.7.10.1 0.663
1ydr IQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4e5f 0N7Polymerase acidic protein / 0.660
2qkr IXMCdc2-like CDK2/CDC28 like protein kinase / 0.659
2c1b CQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
3r8z Z63Cyclin-dependent kinase 2 2.7.11.22 0.654
1ydt IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
4qmz B49Serine/threonine-protein kinase 24 2.7.11.1 0.653
2r64 740Cyclin-dependent kinase 2 2.7.11.22 0.652
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.652
3cxw 7CPSerine/threonine-protein kinase pim-1 2.7.11.1 0.651
4eop 1ROCyclin-dependent kinase 2 2.7.11.22 0.651