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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1oyn ROL cAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1oyn ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 1.079
3g4k ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.943
1q9m ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.900
1xom CIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.856
1tbb ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.846
1xon PILcAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.844
2fm0 M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.837
1ro6 ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B 3.1.4.53 0.822
3g4l ROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.808
2fm5 M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.749
1xoq ROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.739
3g4g D71cAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.719
1mkd ZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.668
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.660
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2puc GUNHTH-type transcriptional repressor PurR / 0.660
4e5i 0N9Polymerase acidic protein / 0.660
4e5l DBHPolymerase acidic protein / 0.660
1vru AAPGag-Pol polyprotein 2.7.7.49 0.651
1xor ZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.650