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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1owi 426 Urokinase-type plasminogen activator 3.4.21.73

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1owi 426Urokinase-type plasminogen activator 3.4.21.73 0.926
1owd 497Urokinase-type plasminogen activator 3.4.21.73 0.787
1owe 675Urokinase-type plasminogen activator 3.4.21.73 0.757
4fud 6UPUrokinase-type plasminogen activator 3.4.21.73 0.732
4fub 4UPUrokinase-type plasminogen activator 3.4.21.73 0.729
4fuj 1U9Urokinase-type plasminogen activator 3.4.21.73 0.720
4fue 7UPUrokinase-type plasminogen activator 3.4.21.73 0.705
2c4f GILCoagulation factor VII 3.4.21.21 0.701
1vja 7INUrokinase-type plasminogen activator 3.4.21.73 0.700
4fui UI3Urokinase-type plasminogen activator 3.4.21.73 0.697
1ghv 120Prothrombin 3.4.21.5 0.696
2v3h I25Prothrombin 3.4.21.5 0.693
2zfq 45UProthrombin 3.4.21.5 0.687
4bam MM9Prothrombin 3.4.21.5 0.684
1ny2 ARG_PRO_PRO_GLYProthrombin 3.4.21.5 0.680
3biv 11UProthrombin 3.4.21.5 0.679
2zi2 24UProthrombin 3.4.21.5 0.676
4bao MVFProthrombin 3.4.21.5 0.675
1gj4 132Prothrombin 3.4.21.5 0.674
2ziq 26UProthrombin 3.4.21.5 0.673
2znk 31UProthrombin 3.4.21.5 0.673
1c5n ESIProthrombin 3.4.21.5 0.672
2zg0 50UProthrombin 3.4.21.5 0.669
3utu 1TSProthrombin 3.4.21.5 0.664
2bdy UNBProthrombin 3.4.21.5 0.661
1drt PCVClavaminate synthase 1 1.14.11.21 0.660
1c4u IH1Prothrombin 3.4.21.5 0.659
2zgx 29UProthrombin 3.4.21.5 0.658
1wtg 3BPCoagulation factor VII 3.4.21.21 0.657
1k22 MELProthrombin 3.4.21.5 0.655
2zhe 13UProthrombin 3.4.21.5 0.653
1c1w BAHProthrombin 3.4.21.5 0.652
1o0d 163Prothrombin 3.4.21.5 0.652
2bok 784Coagulation factor X 3.4.21.6 0.652
2zhf 49UProthrombin 3.4.21.5 0.652