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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ot7 CHC Bile acid receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ot7 CHCBile acid receptor / 1.453
1osv CHCBile acid receptor / 1.219
4qe6 JN3Bile acid receptor / 0.931
3gyu DL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily / 0.713
3up3 XCAaceDAF-12 / 0.704
4ofr DHTAndrogen receptor / 0.691
1zhy CLROxysterol-binding protein homolog 4 / 0.678
3f3y 4OABile salt sulfotransferase 2.8.2.14 0.678
1zhw HC2Oxysterol-binding protein homolog 4 / 0.673
3w5t LHPVitamin D3 receptor / 0.673
2j7y E3OEstrogen receptor beta / 0.664
3s79 ASDAromatase 1.14.14.14 0.661
2q7i TESAndrogen receptor / 0.660
4czt CPSCBL-interacting serine/threonine-protein kinase 23 2.7.11.1 0.660
2pkl DHTAndrogen receptor / 0.658
3gkj HC3Niemann-Pick C1 protein / 0.658
4a83 DXCMajor pollen allergen Bet v 1-A / 0.658
4ia2 BIVVitamin D3 receptor A / 0.658
2q7k TESAndrogen receptor / 0.656
1gwr ESTEstrogen receptor / 0.654
1ahi CHO7-alpha-hydroxysteroid dehydrogenase 1.1.1.159 0.652
5l7d CLRSmoothened homolog / 0.652