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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ol6 ATP Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ol6 ATPAurora kinase A 2.7.11.1 0.899
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.764
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.758
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.754
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.750
5dnr ATPAurora kinase A 2.7.11.1 0.750
5dt3 ATPAurora kinase A 2.7.11.1 0.748
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.747
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.747
5dn3 ATPAurora kinase A 2.7.11.1 0.744
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.743
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.736
4utd ACPAurora kinase A 2.7.11.1 0.734
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.733
4dee ADPAurora kinase A 2.7.11.1 0.733
4ceg ADPAurora kinase A 2.7.11.1 0.728
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.727
5dos ATPAurora kinase A 2.7.11.1 0.727
1mq4 ADPAurora kinase A 2.7.11.1 0.726
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.726
4o4e ATPKinase / 0.725
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.724
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.724
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.722
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.720
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.719
2pul ACPMethylthioribose kinase 2.7.1.100 0.719
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.719
5dr2 ATPAurora kinase A 2.7.11.1 0.719
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.718
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.718
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.717
5dt4 ATPAurora kinase A 2.7.11.1 0.717
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.716
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.716
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.716
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.715
2pui ADPMethylthioribose kinase 2.7.1.100 0.713
5drd ATPAurora kinase A 2.7.11.1 0.713
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.712
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.712
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.711
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.711
2olc ADPMethylthioribose kinase 2.7.1.100 0.710
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.709
3c50 ADPRhodopsin kinase / 0.708
3c4z ADPRhodopsin kinase / 0.707
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.706
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.704
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.703
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.701
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.700
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.700
3t8o ATPRhodopsin kinase / 0.699
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.699
4o4f ATPKinase / 0.698
2pun ACPMethylthioribose kinase 2.7.1.100 0.697
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.697
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.697
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.696
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.695
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.695
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.695
1u54 ACPActivated CDC42 kinase 1 / 0.693
2pyw ADPMethylthioribose kinase 2.7.1.100 0.693
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.692
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.692
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.692
2dwb ANPAurora kinase A 2.7.11.1 0.691
4c3r ACPAurora kinase A 2.7.11.1 0.691
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.690
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.690
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.690
5ckw ANPUncharacterized protein / 0.690
2wqe ADPAurora kinase A 2.7.11.1 0.689
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.689
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
2py3 ACPFibroblast growth factor receptor 2 / 0.686
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.685
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.685
4bn1 ADPAurora kinase A 2.7.11.1 0.685
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.685
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.685
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.683
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.682
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.682
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.681
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.679
3cly ACPFibroblast growth factor receptor 2 / 0.678
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.678
4q5j ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.677
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.677
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.676
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.676
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.675
2pup ADPMethylthioribose kinase 2.7.1.100 0.674
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.674
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.673
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.672
3llt ANPProtein serine/threonine kinase-1 / 0.672
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.672
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.672
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.671
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.670
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.670
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.670
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.670
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.669
2yaa ATPDeath-associated protein kinase 2 / 0.669
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.669
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.669
4xlv ACPInsulin receptor 2.7.10.1 0.669
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.668
2pz5 ACPFibroblast growth factor receptor 2 / 0.668
2vqd AP2Biotin carboxylase 6.3.4.14 0.668
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.668
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.668
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.667
3q5i ANPProtein kinase, putative / 0.667
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
3ork AGSSerine/threonine protein kinase / 0.666
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.666
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.666
4qny ANPMitogen activated protein kinase, putative / 0.666
3orm AGSSerine/threonine protein kinase / 0.665
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.665
5eg3 ACPFibroblast growth factor receptor 2 / 0.665
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.664
2pzp ACPFibroblast growth factor receptor 2 / 0.663
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.663
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.663
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.661
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.661
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.661
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.661
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.660
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.660
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.660
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.660
4gyi ADPUncharacterized protein / 0.660
5l8j ADPAurora kinase A 2.7.11.1 0.660
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.659
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.659
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.659
5iqh GNPBifunctional AAC/APH 2.3.1 0.659
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.658
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.658
3qc9 ADPRhodopsin kinase / 0.658
5iqb GNPBifunctional AAC/APH 2.3.1 0.657
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.656
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.656
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.655
4o0u ADNAurora kinase A 2.7.11.1 0.655
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.655
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.654
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.654
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4o1p ANPRibonuclease L / 0.654
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.654
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.653
4ffm ADPUncharacterized protein / 0.652
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.651
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.651
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.651
3kmw ATPIntegrin-linked protein kinase 2.7.11.1 0.651
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.651
5c03 AGSNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.651
1cm8 ANPMitogen-activated protein kinase 12 / 0.650
1pjk ANPCasein kinase II subunit alpha 2.7.11.1 0.650
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
3rv4 ADPBiotin carboxylase 6.3.4.14 0.650
4fvq ATPTyrosine-protein kinase JAK2 / 0.650