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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1oir HDY Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1oir HDYCyclin-dependent kinase 2 2.7.11.22 0.872
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.746
2wip P49Cyclin-dependent kinase 2 2.7.11.22 0.727
2c5n CK8Cyclin-dependent kinase 2 2.7.11.22 0.724
1pxm CK5Cyclin-dependent kinase 2 2.7.11.22 0.710
2wih P48Cyclin-dependent kinase 2 2.7.11.22 0.699
3cgo JNOMitogen-activated protein kinase 10 2.7.11.24 0.690
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.683
1oit HDTCyclin-dependent kinase 2 2.7.11.22 0.682
1y57 MPZProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.680
1pxp CK8Cyclin-dependent kinase 2 2.7.11.22 0.679
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.679
3elj GS7Mitogen-activated protein kinase 8 2.7.11.24 0.677
4aot GW8Serine/threonine-protein kinase 10 2.7.11.1 0.677
1pxo CK7Cyclin-dependent kinase 2 2.7.11.22 0.673
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.672
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.668
2jkq VG8Focal adhesion kinase 1 2.7.10.2 0.667
3cjf SAVVascular endothelial growth factor receptor 2 2.7.10.1 0.664
4a4o 664Serine/threonine-protein kinase PLK1 2.7.11.21 0.664
2w17 I19Cyclin-dependent kinase 2 2.7.11.22 0.663
3cjg KIMVascular endothelial growth factor receptor 2 2.7.10.1 0.663
2c5y MTWCyclin-dependent kinase 2 2.7.11.22 0.660
3o0g 3O0Cyclin-dependent-like kinase 5 2.7.11.1 0.658
2w06 FRVCyclin-dependent kinase 2 2.7.11.22 0.656
5ap7 SVEDual specificity protein kinase TTK 2.7.12.1 0.655
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.653
2vv9 IM9Cyclin-dependent kinase 2 2.7.11.22 0.652
4ek8 16KCyclin-dependent kinase 2 2.7.11.22 0.652