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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ohk COP Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ohk COPDihydrofolate reductase 1.5.1.3 1.105
1dls MTXDihydrofolate reductase 1.5.1.3 0.789
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.762
1hfp MOTDihydrofolate reductase 1.5.1.3 0.739
1drf FOLDihydrofolate reductase 1.5.1.3 0.738
4keb FOLDihydrofolate reductase 1.5.1.3 0.736
1dre MTXDihydrofolate reductase 1.5.1.3 0.734
5hi6 MTXDihydrofolate reductase / 0.734
4m6k FOLDihydrofolate reductase 1.5.1.3 0.733
4kfj FOLDihydrofolate reductase 1.5.1.3 0.731
3ghw GHWDihydrofolate reductase 1.5.1.3 0.728
1ohj COPDihydrofolate reductase 1.5.1.3 0.725
4m6l 21VDihydrofolate reductase 1.5.1.3 0.724
3eig MTXDihydrofolate reductase 1.5.1.3 0.723
1u72 MTXDihydrofolate reductase 1.5.1.3 0.721
3tqb FOLDihydrofolate reductase / 0.716
1hfq MOTDihydrofolate reductase 1.5.1.3 0.715
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.714
1dyh DZFDihydrofolate reductase 1.5.1.3 0.711
4i1n FOLDihydrofolate reductase 1.5.1.3 0.710
1dhf FOLDihydrofolate reductase 1.5.1.3 0.708
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.708
2w3m FOLDihydrofolate reductase 1.5.1.3 0.708
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.707
2zza FOLDihydrofolate reductase / 0.706
3drc MTXDihydrofolate reductase 1.5.1.3 0.706
4i13 FOLDihydrofolate reductase 1.5.1.3 0.706
3dfr MTXDihydrofolate reductase 1.5.1.3 0.704
3td8 D2RDihydrofolate reductase 1.5.1.3 0.702
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.702
3tq9 MTXDihydrofolate reductase / 0.698
1df7 MTXDihydrofolate reductase 1.5.1.3 0.697
2qk8 MTXDihydrofolate reductase / 0.697
1hfr MOTDihydrofolate reductase 1.5.1.3 0.696
3dau MTXDihydrofolate reductase 1.5.1.3 0.696
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.696
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.695
4dfr MTXDihydrofolate reductase 1.5.1.3 0.693
1u70 MTXDihydrofolate reductase 1.5.1.3 0.687
4x5h FOLDihydrofolate reductase 1.5.1.3 0.686
4x5i FOLDihydrofolate reductase 1.5.1.3 0.686
3dat MTXDihydrofolate reductase / 0.679
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.673
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.666
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.664
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.663
3ghv GHCDihydrofolate reductase 1.5.1.3 0.662
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.661
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.658
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.657
2drc MTXDihydrofolate reductase 1.5.1.3 0.656
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.652
4ie5 MD6Alpha-ketoglutarate-dependent dioxygenase FTO / 0.652
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.651
4qi9 MTXDihydrofolate reductase / 0.651
4p66 MTXDihydrofolate reductase / 0.650