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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1oec AA2 Fibroblast growth factor receptor 2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1oec AA2Fibroblast growth factor receptor 2 / 0.850
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
3uo5 0BXAurora kinase A 2.7.11.1 0.712
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.701
4b0g VEKAurora kinase A 2.7.11.1 0.699
2xch CKG3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.688
4im0 1FVSerine/threonine-protein kinase TBK1 2.7.11.1 0.684
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.682
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.682
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.675
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.675
4f64 0S8Fibroblast growth factor receptor 1 / 0.672
5dr9 SKEAurora kinase A 2.7.11.1 0.671
3ztx ZTXAurora kinase B-A 2.7.11.1 0.670
4d58 BI9Focal adhesion kinase 1 2.7.10.2 0.670
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.667
3w16 P9JAurora kinase A 2.7.11.1 0.666
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.665
1gij 2PUCyclin-dependent kinase 2 2.7.11.22 0.663
1z5m LI83-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.663
3cjf SAVVascular endothelial growth factor receptor 2 2.7.10.1 0.662
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.660
2x4f 16XMyosin light chain kinase family member 4 2.7.11.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4im2 BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.660
3h3c P1EProtein-tyrosine kinase 2-beta 2.7.10.2 0.659
4eut BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.659
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.657
4f63 0S7Fibroblast growth factor receptor 1 / 0.656
2wip P49Cyclin-dependent kinase 2 2.7.11.22 0.655
1gii 1PUCyclin-dependent kinase 2 2.7.11.22 0.654
2jkq VG8Focal adhesion kinase 1 2.7.10.2 0.652
3i60 E86Mitogen-activated protein kinase 1 2.7.11.24 0.652
5ap7 SVEDual specificity protein kinase TTK 2.7.12.1 0.652
3cjg KIMVascular endothelial growth factor receptor 2 2.7.10.1 0.651
4d4s BI9Focal adhesion kinase 1 2.7.10.2 0.651