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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1o94 ADP Trimethylamine dehydrogenase 1.5.8.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.878
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.868
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.867
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.864
4gcm FADThioredoxin reductase 1.8.1.9 0.791
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.765
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.753
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.750
1zx9 FADMercuric reductase 1.16.1.1 0.743
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.743
1y56 ATPUncharacterized protein / 0.736
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.734
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.734
4h4y FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.733
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.732
4icy FADPgaE / 0.732
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.727
2zbw FADFerredoxin--NADP reductase / 0.727
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.725
3gwf FADCyclohexanone monooxygenase / 0.722
2gr1 FADFerredoxin reductase / 0.719
2yvf FADFerredoxin reductase / 0.717
4j33 FADKynurenine 3-monooxygenase / 0.715
2q7v FADThioredoxin reductase / 0.713
4h50 FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.713
1f3p FADFerredoxin reductase / 0.712
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.712
1zk7 FADMercuric reductase 1.16.1.1 0.711
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.707
3gwd FADCyclohexanone monooxygenase / 0.706
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.705
1tdf FADThioredoxin reductase 1.8.1.9 0.703
3f8p NADNADH oxidase/thioredoxin reductase / 0.702
2qa1 FADPgaE / 0.701
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.701
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.701
4guu FA9Lysine-specific histone demethylase 1B 1 0.701
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.701
3cty FADProbable thioredoxin reductase / 0.699
3fpz AHZThiamine thiazole synthase / 0.698
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.698
1ger FADGlutathione reductase 1.8.1.7 0.697
4k2x FADPolyketide oxygenase/hydroxylase / 0.697
3k30 ADPHistamine dehydrogenase / 0.696
3r9u FADThioredoxin reductase / 0.696
1get FADGlutathione reductase 1.8.1.7 0.695
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.695
2qa2 FADPolyketide oxygenase CabE / 0.695
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.694
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.694
4j34 FADKynurenine 3-monooxygenase / 0.694
1gxf FADTrypanothione reductase 1.8.1.12 0.693
2xvf FADPutative flavin-containing monooxygenase / 0.693
4ntc FADThioredoxin reductase gliT / 0.693
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.692
2hqm FADGlutathione reductase 1.8.1.7 0.692
4gut FADLysine-specific histone demethylase 1B 1 0.692
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.691
2apg FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.691
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.691
4hb9 FADUncharacterized protein / 0.691
1ryi FADGlycine oxidase 1.4.3.19 0.690
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.690
3cgd FADCoenzyme A disulfide reductase / 0.690
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.690
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.689
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.689
2hko FADLysine-specific histone demethylase 1A 1 0.689
2yg6 FADPutrescine oxidase / 0.689
3he3 FADUDP-galactopyranose mutase / 0.689
1cl0 FADThioredoxin reductase 1.8.1.9 0.688
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.688
3gsi FADDimethylglycine oxidase 1.5.3.10 0.688
3qj4 FADRenalase / 0.688
4cnk FADL-amino acid oxidase / 0.688
4fwf FADLysine-specific histone demethylase 1B 1 0.688
4h4q FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.688
1tde FADThioredoxin reductase 1.8.1.9 0.687
4ntd FADThioredoxin reductase / 0.687
2wba FADTrypanothione reductase 1.8.1.12 0.685
2yg5 FADPutrescine oxidase / 0.685
2eq7 FADDihydrolipoyl dehydrogenase / 0.684
3nlc FADUncharacterized protein / 0.684
3mj4 FADUDP-galactopyranose mutase / 0.683
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.683
4fk1 FADPutative thioredoxin reductase / 0.683
4j36 FADKynurenine 3-monooxygenase / 0.683
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.683
1d7y FADFerredoxin reductase / 0.682
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.682
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.681
2cvj FADThioredoxin reductase related protein / 0.681
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.681
3atr FDAConserved Archaeal protein / 0.681
3f8d FADNADH oxidase/thioredoxin reductase / 0.681
2eq6 FADDihydrolipoyl dehydrogenase / 0.680
3ad9 NADSubunit alpha of sarocosine oxidase / 0.680
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.679
1qo8 FADFumarate reductase flavoprotein subunit / 0.679
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.679
2iw5 FADLysine-specific histone demethylase 1A 1 0.679
1geu FADGlutathione reductase 1.8.1.7 0.678
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.678
2yg3 FADPutrescine oxidase / 0.678
2yg4 FADPutrescine oxidase / 0.677
3cge FADCoenzyme A disulfide reductase / 0.677
3sz0 FADSulfide-quinone reductase / 0.677
3ute FADUDP-galactopyranose mutase / 0.677
4la1 FADThioredoxin glutathione reductase / 0.677
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.677
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.676
2aqj FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.675
3cgb FADCoenzyme A disulfide reductase / 0.675
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.675
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.675
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.675
3ish FADThioredoxin reductase 1.8.1.9 0.675
3t2y FADSulfide-quinone reductase / 0.675
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.675
4xbf FADLysine-specific histone demethylase 1A 1 0.675
1trb FADThioredoxin reductase 1.8.1.9 0.674
2gr0 FADFerredoxin reductase / 0.674
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.674
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.674
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.674
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.674
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.674
4nzh FADL-ornithine N(5)-monooxygenase / 0.674
5l3d FADLysine-specific histone demethylase 1A 1 0.674
1feb FADTrypanothione reductase 1.8.1.12 0.673
2iid FADL-amino-acid oxidase 1.4.3.2 0.673
2wow FADTrypanothione reductase / 0.673
3lad FADDihydrolipoyl dehydrogenase / 0.673
3lsi FADPyranose 2-oxidase / 0.673
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.673
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.673
1fec FADTrypanothione reductase 1.8.1.12 0.672
2cul FADGidA-related protein / 0.672
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.672
3kpk FADSulfide-quinone reductase / 0.672
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.672
5dbj FADFADH2-dependent halogenase PltA / 0.672
1f8s FADL-amino-acid oxidase 1.4.3.2 0.670
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.670
3kpf FADPolyamine oxidase 1.5.3.14 0.670
4ap1 FADSteroid monooxygenase / 0.670
4bjz FADProbable salicylate monooxygenase / 0.670
2r0c FADPutative FAD-monooxygenase / 0.669
2tpr FADTrypanothione reductase 1.8.1.12 0.669
3f8r NAPNADH oxidase/thioredoxin reductase / 0.669
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.669
3vqr FADPutative oxidoreductase / 0.669
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.669
1f8r FADL-amino-acid oxidase 1.4.3.2 0.668
2gqw FADFerredoxin reductase / 0.668
2yqu FADDihydrolipoyl dehydrogenase / 0.668
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.668
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.668
2eq8 FADDihydrolipoyl dehydrogenase / 0.667
2whd FADThioredoxin reductase / 0.667
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.667
3urh FADDihydrolipoyl dehydrogenase / 0.667
4j57 FADThioredoxin reductase 2 1.8.1.9 0.667
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.666
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.665
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.665
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.665
2xve FADPutative flavin-containing monooxygenase / 0.665
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.665
3rha FDAPutrescine oxidase / 0.665
4jnq FDAThioredoxin reductase / 0.665
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.664
2rgh FADAlpha-Glycerophosphate Oxidase / 0.664
4cnj FADL-amino acid oxidase / 0.664
4nev FADTrypanothione reductase / 0.664
2eq7 NADDihydrolipoyl dehydrogenase / 0.663
2uxx FAJLysine-specific histone demethylase 1A 1 0.663
3ad9 FADSubunit beta of sarcosine oxidase / 0.663
3ada NADSubunit alpha of sarocosine oxidase / 0.663
3cgc FADCoenzyme A disulfide reductase / 0.663
4b69 FADL-ornithine N(5)-monooxygenase / 0.663
5c2t FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.663
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.663
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.662
3jsk AHZThiamine thiazole synthase / 0.662
4k5r FADOxygenase / 0.662
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.662
1pdh FASp-hydroxybenzoate hydroxylase / 0.661
2dw4 FADLysine-specific histone demethylase 1A 1 0.661
3t37 FADPyridoxine 4-oxidase / 0.661
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.661
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.661
2gr3 FADFerredoxin reductase / 0.660
2yg7 FADPutrescine oxidase / 0.660
3syi FADSulfide-quinone reductase / 0.660
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.660
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.660
4jn9 FADDepH / 0.660
4nte FADDepH / 0.660
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.659
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.659
2q0k FADThioredoxin reductase 1.8.1.9 0.659
2x3n FADProbable FAD-dependent monooxygenase / 0.659
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.659
4b63 FADL-ornithine N(5)-monooxygenase / 0.659
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.659
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.658
3t2k FADSulfide-quinone reductase / 0.658
4j2w FADKynurenine 3-monooxygenase / 0.658
4z43 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.658
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.657
2eq9 FADDihydrolipoyl dehydrogenase / 0.657
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.657
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.657
4z44 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.657
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.656
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.656
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.656
2ar8 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.656
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.656
3if9 FADGlycine oxidase 1.4.3.19 0.656
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.656
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.656
4fwe FADLysine-specific histone demethylase 1B 1 0.656
1rsg FADPolyamine oxidase FMS1 / 0.655
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.655
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.655
4dsg FADUncharacterized protein / 0.655
4ysh FADGlycine oxidase / 0.655
1ng4 FADGlycine oxidase 1.4.3.19 0.654
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.654
2du8 FADD-amino-acid oxidase 1.4.3.3 0.654
2x8g FADThioredoxin glutathione reductase / 0.654
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.654
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.654
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.653
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.653
2jae FADL-amino acid oxidase / 0.653
2rab FADGlutathione amide reductase / 0.653
3bi2 FADPolyamine oxidase FMS1 / 0.653
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.653
1cbo FADCholesterol oxidase 1.1.3.6 0.652
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.652
2jk6 FADTrypanothione reductase / 0.652
3atq FDAConserved Archaeal protein / 0.652
3cn8 FADPolyamine oxidase FMS1 / 0.652
3rp8 FADFAD-dependent urate hydroxylase / 0.652
4bur FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.652
5hxw FADL-amino acid deaminase / 0.652
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.651
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.651
2y48 FADLysine-specific histone demethylase 1A 1 0.651
3ihg FADAklavinone 12-hydroxylase RdmE / 0.651
3nix FADFlavoprotein/dehydrogenase / 0.651
4gus FADLysine-specific histone demethylase 1B 1 0.651
4mih FADPyranose 2-oxidase 1.1.3.10 0.651
1q1r FADPutidaredoxin reductase 1.18.1.5 0.650
2c31 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.650
2gv8 FADThiol-specific monooxygenase 1.14.13 0.650
2igo FADPyranose 2-oxidase / 0.650
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.650
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.650