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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1o0s NAI NAD-dependent malic enzyme, mitochondrial 1.1.1.38

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1o0s NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.996
1llq NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.780
1pj2 NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.727
4ebf NADPhosphonate dehydrogenase 1.20.1.1 0.706
1efl NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.700
1pj4 ATPNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.699
3cea NADMyo-inositol 2-dehydrogenase-like (Promiscuous) / 0.691
1pj3 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.688
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.677
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.675
4xcv NDPProbable hydroxyacid dehydrogenase protein / 0.667
3p2o NADBifunctional protein FolD / 0.666
3x2f NAIAdenosylhomocysteinase / 0.663
1gz4 ATPNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.662
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.662
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.661
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.656
2ahr NAPPyrroline-5-carboxylate reductase / 0.653
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.652
3anm NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.652
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.652
1f17 NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.651
1o6z NADMalate dehydrogenase / 0.650