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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1o01 NAD Aldehyde dehydrogenase, mitochondrial 1.2.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.170
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.103
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.040
1bxs NADRetinal dehydrogenase 1 1.2.1.36 1.025
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.007
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.978
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.974
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.971
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.967
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.918
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.892
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.881
4pt0 NADAldehyde dehydrogenase / 0.850
4pxl NADAldehyde dehydrogenase3 / 0.840
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.836
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.814
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.808
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.805
4pz2 NADAldehyde dehydrogenase 2-6 / 0.791
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.784
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.784
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.773
4i9b NADPutative betaine aldehyde dehyrogenase / 0.772
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.765
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.762
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.761
4pt3 NDPAldehyde dehydrogenase / 0.761
3iwj NADAminoaldehyde dehydrogenase / 0.758
4i8q NADPutative betaine aldehyde dehyrogenase / 0.754
4i8p NADAminoaldehyde dehydrogenase 1 / 0.753
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.751
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.739
3b4w NADAldehyde dehydrogenase family protein / 0.738
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.735
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.735
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.735
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.730
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.730
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.728
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.727
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.725
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.723
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.722
4f3x NADPutative aldehyde dehydrogenase / 0.722
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.721
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.717
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.716
5eyu NADBetaine-aldehyde dehydrogenase / 0.715
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.714
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.713
4i3v NADAldehyde dehydrogenase (NAD+) / 0.711
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.709
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.709
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.707
4i3w NADAldehyde dehydrogenase (NAD+) / 0.705
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.701
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.696
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.693
5ez4 NADBetaine-aldehyde dehydrogenase / 0.691
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.688
4h73 NDPAldehyde dehydrogenase / 0.688
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.687
1bi9 NADRetinal dehydrogenase 2 / 0.686
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.685
2w8r ADPSuccinate-semialdehyde dehydrogenase, mitochondrial 1.2.1.24 0.684
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.684
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.683
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.682
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.682
5dib NADBetaine-aldehyde dehydrogenase / 0.680
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.678
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.674
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.671
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.671
2onm ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.667
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.664
2jg7 NADAntiquitin / 0.663
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.660
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.659
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.654
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.654
2y53 NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.651