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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1nzz NAI Aldehyde dehydrogenase, mitochondrial 1.2.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.203
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.094
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.065
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.048
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.007
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.998
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.985
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.930
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.924
4pxl NADAldehyde dehydrogenase3 / 0.904
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.900
4pt0 NADAldehyde dehydrogenase / 0.867
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.860
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.819
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.814
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.805
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.802
4pt3 NDPAldehyde dehydrogenase / 0.776
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.752
5ez4 NADBetaine-aldehyde dehydrogenase / 0.741
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.740
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.740
5dib NADBetaine-aldehyde dehydrogenase / 0.724
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.723
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.720
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.718
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.713
5eyu NADBetaine-aldehyde dehydrogenase / 0.703
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.702
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.702
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.702
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.700
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.700
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.698
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.691
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.691
2w8r ADPSuccinate-semialdehyde dehydrogenase, mitochondrial 1.2.1.24 0.690
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.690
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.687
3b4w NADAldehyde dehydrogenase family protein / 0.687
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.687
4i8p NADAminoaldehyde dehydrogenase 1 / 0.684
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.681
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.678
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.673
2onm ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.672
4i8q NADPutative betaine aldehyde dehyrogenase / 0.669
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.668
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.666
4i3v NADAldehyde dehydrogenase (NAD+) / 0.666
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.661
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.659
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.658
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.657
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.657
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.656
2y53 NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.655
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.651
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.650