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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1njb UMP Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1njb UMPThymidylate synthase / 0.925
1nje DCMThymidylate synthase / 0.780
1bp6 UMPThymidylate synthase / 0.776
1njd UMPThymidylate synthase / 0.766
1bp0 UMPThymidylate synthase / 0.765
1nja DCMThymidylate synthase / 0.755
1jmi UMPThymidylate synthase / 0.752
1tsv UMPThymidylate synthase / 0.750
1tsy UMPThymidylate synthase / 0.744
2tdm UMPThymidylate synthase / 0.744
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.743
1vzb UMPThymidylate synthase / 0.740
1jmh UMPThymidylate synthase / 0.736
5by6 UMPThymidylate synthase / 0.710
2g89 UMPThymidylate synthase / 0.706
1bid UMPThymidylate synthase / 0.701
1njc DCMThymidylate synthase / 0.700
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.699
1f28 UMPThymidylate synthase 2.1.1.45 0.693
1tsx UMPThymidylate synthase / 0.693
1bpj UMPThymidylate synthase / 0.689
4isk UMPThymidylate synthase / 0.686
4psg NOHThymidylate synthase / 0.685
1ddu DDUThymidylate synthase / 0.683
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.677
4dq1 UMPThymidylate synthase / 0.675
4iqq UMPThymidylate synthase / 0.673
1vza UMPThymidylate synthase / 0.672
2vet UMPThymidylate synthase / 0.672
4ein NOHThymidylate synthase 2.1.1.45 0.670
2g8a UMPThymidylate synthase / 0.664
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.663
4fox UMPThymidylate synthase ThyA / 0.663
1ci7 UMPThymidylate synthase 2.1.1.45 0.662
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.655
2fto TMPThymidylate synthase / 0.654
2g8d UMPThymidylate synthase / 0.652