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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1nc1 MTH 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 3.2.2.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1nc1 MTH5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 3.2.2.9 1.121
1y6r MTM5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 3.2.2.9 0.945
3eei MTM5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase / 0.908
4bmz MTAAminodeoxyfutalosine nucleosidase / 0.895
1zos MTM5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase / 0.772
4x24 TDI5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase / 0.760
1y6q TDI5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 3.2.2.9 0.737
1jdv ADNPurine nucleoside phosphorylase / 0.721
2qtg MTH5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1 3.2.2.9 0.715
4wkb TDI5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase / 0.715
3fow IMHPurine nucleoside phosphorylase / 0.708
4ts9 FMCPurine nucleoside phosphorylase DeoD-type / 0.708
1je1 GMPPurine nucleoside phosphorylase / 0.705
2hwu URIUridine phosphorylase 2.4.2.3 0.698
1pr0 NOSPurine nucleoside phosphorylase DeoD-type / 0.696
1pk9 2FAPurine nucleoside phosphorylase DeoD-type / 0.694
4ttj FMCPurine nucleoside phosphorylase DeoD-type / 0.691
2bzg SAHThiopurine S-methyltransferase 2.1.1.67 0.690
2zfu SAHRibosomal RNA-processing protein 8 / 0.684
1kph SAHCyclopropane mycolic acid synthase 1 2.1.1.79 0.681
1a69 FMBPurine nucleoside phosphorylase DeoD-type / 0.672
4dae 6CRPurine nucleoside phosphorylase DeoD-type 2.4.2.1 0.672
2qg4 UGAUDP-glucose 6-dehydrogenase 1.1.1.22 0.667
2pkk 2FAAdenosine kinase 2.7.1.20 0.664
2q3e UPGUDP-glucose 6-dehydrogenase 1.1.1.22 0.664
4f0r MTA5-methylthioadenosine/S-adenosylhomocysteine deaminase / 0.664
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.663
3bgi SAHThiopurine S-methyltransferase 2.1.1.67 0.663
2i4t UA2Purine nucleoside phosphorylase, putative / 0.657
3uaw ADNPurine nucleoside phosphorylase DeoD-type / 0.656
3vc1 SAHGeranyl diphosphate 2-C-methyltransferase 2.1.1.255 0.654
4tti FMCPurine nucleoside phosphorylase DeoD-type / 0.654
1h6b NDPGlucose--fructose oxidoreductase 1.1.99.28 0.652
3grr SAHProbable ribosomal RNA small subunit methyltransferase A / 0.652
4o8j ADNRNA 3'-terminal phosphate cyclase 6.5.1.4 0.652
1h6d NDPGlucose--fructose oxidoreductase 1.1.99.28 0.651
4tta FMCPurine nucleoside phosphorylase DeoD-type / 0.651