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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1n95 HFP Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1n95 HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha / 1.050
1n95 HFPProtein farnesyltransferase subunit beta 2.5.1.58 1.050
1qbq HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha / 0.948
1qbq HFPProtein farnesyltransferase subunit beta 2.5.1.58 0.948
1ni1 HFPProtein farnesyltransferase subunit beta 2.5.1.58 0.849
1nl4 HFPProtein farnesyltransferase subunit beta 2.5.1.58 0.798
3ksl SZHProtein farnesyltransferase subunit beta 2.5.1.58 0.707
1o1s 1NHProtein farnesyltransferase subunit beta 2.5.1.58 0.668
1bp6 UMPThymidylate synthase / 0.661
2tdm UMPThymidylate synthase / 0.654