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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1mb4 NDP Aspartate-semialdehyde dehydrogenase 1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1mb4 NDPAspartate-semialdehyde dehydrogenase 1 / 1.112
3pzr NAPAspartate-semialdehyde dehydrogenase 1 / 0.810
5bnt NAPAspartate-semialdehyde dehydrogenase 1.2.1.11 0.785
3wyc NAPMeso-diaminopimelate D-dehydrogenase 1.4.1.16 0.674
2oby NAPQuinone oxidoreductase PIG3 1 0.668
5eio NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.668
4iqq UMPThymidylate synthase / 0.667
4b7x NAPProbable oxidoreductase / 0.662
1vc2 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.661
2fto TMPThymidylate synthase / 0.661
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.660
4yaw 2AMNADPH--cytochrome P450 reductase / 0.658
1f06 NDPMeso-diaminopimelate D-dehydrogenase 1.4.1.16 0.657
2b4r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.656
4e5p NADPhosphonate dehydrogenase 1.20.1.1 0.656
4j49 NADUncharacterized protein / 0.655
3n14 FMNXenobiotic reductase / 0.653
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.653
3s87 DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.652