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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1m0w ANP Glutathione synthetase 6.3.2.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1m0w ANPGlutathione synthetase 6.3.2.3 1.095
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.810
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.802
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.798
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.791
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.784
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.776
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.773
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.768
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.763
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.763
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.759
2py3 ACPFibroblast growth factor receptor 2 / 0.758
2zdg ADPD-alanine--D-alanine ligase / 0.758
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.757
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.757
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.756
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.756
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.752
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.751
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.751
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.750
5byl GCPBifunctional AAC/APH 2.3.1 0.750
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.745
3cly ACPFibroblast growth factor receptor 2 / 0.744
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.743
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.741
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.739
4bn1 ADPAurora kinase A 2.7.11.1 0.739
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.735
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.734
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.734
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.733
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.733
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.733
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.732
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.731
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.730
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.730
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.729
2pz5 ACPFibroblast growth factor receptor 2 / 0.728
2pzp ACPFibroblast growth factor receptor 2 / 0.726
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.724
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.723
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.723
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.721
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.721
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.721
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.719
2pyw ADPMethylthioribose kinase 2.7.1.100 0.718
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.718
2pui ADPMethylthioribose kinase 2.7.1.100 0.714
4o4d ATPKinase / 0.712
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.711
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.711
1cm8 ANPMitogen-activated protein kinase 12 / 0.710
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.710
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.710
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.708
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.707
4uxx ACPDiacylglycerol kinase 2.7.1.107 0.707
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.706
4ceg ADPAurora kinase A 2.7.11.1 0.706
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.705
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.704
2pul ACPMethylthioribose kinase 2.7.1.100 0.703
3wnz ADPAlanine--anticapsin ligase / 0.703
4ffm ADPUncharacterized protein / 0.702
2p0a ANPSynapsin-3 / 0.701
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.701
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.701
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.700
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.699
1mq4 ADPAurora kinase A 2.7.11.1 0.699
4ffr ATPUncharacterized protein / 0.699
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.698
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.697
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.697
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.696
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.696
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.696
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.695
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.695
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.695
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
3lmi ATPMyosin heavy chain kinase A 2.7.11.7 0.695
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.694
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.694
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.693
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.693
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.693
4utd ACPAurora kinase A 2.7.11.1 0.693
3t8o ATPRhodopsin kinase / 0.690
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
5dt3 ATPAurora kinase A 2.7.11.1 0.689
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.688
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.688
5iqb GNPBifunctional AAC/APH 2.3.1 0.688
3c4z ADPRhodopsin kinase / 0.687
3c50 ADPRhodopsin kinase / 0.687
4ffl ADPUncharacterized protein / 0.687
4qny ANPMitogen activated protein kinase, putative / 0.687
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.686
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.686
5c1o ANPD-alanine--D-alanine ligase / 0.685
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.685
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.683
3wo0 ADPAlanine--anticapsin ligase / 0.683
4dee ADPAurora kinase A 2.7.11.1 0.683
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.682
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.682
1pk8 ATPSynapsin-1 / 0.681
3pdt ADPMyosin heavy chain kinase A 2.7.11.7 0.681
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.681
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.680
3qc9 ADPRhodopsin kinase / 0.680
5ce3 ADPProtein kinase YopO / 0.679
5eg3 ACPFibroblast growth factor receptor 2 / 0.679
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.677
5iqh GNPBifunctional AAC/APH 2.3.1 0.677
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.676
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.675
4ix5 ANPUncharacterized protein / 0.675
4lrj ANPUncharacterized protein / 0.675
3tw6 ADPPyruvate carboxylase / 0.674
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.674
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.674
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.674
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.673
1t36 ADPCarbamoyl-phosphate synthase large chain / 0.672
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.672
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.672
3rv4 ADPBiotin carboxylase 6.3.4.14 0.672
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.672
2j9g ANPBiotin carboxylase 6.3.4.14 0.671
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.671
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.670
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
4wh3 ATPN-acetylhexosamine 1-kinase 2.7.1.162 0.670
4ysj ADPCalmodulin-like domain protein kinase / 0.670
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.669
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.668
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.668
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.667
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.667
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.666
3lmh ADPMyosin heavy chain kinase A 2.7.11.7 0.666
5iqe GNPBifunctional AAC/APH 2.3.1 0.665
5iqi GNPBifunctional AAC/APH 2.3.1 0.665
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.664
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.663
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.663
3wo1 ADPAlanine--anticapsin ligase / 0.663
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.662
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.662
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.661
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.661
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.661
5dn3 ATPAurora kinase A 2.7.11.1 0.661
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.660
5iqg GDPBifunctional AAC/APH 2.3.1 0.660
3r5f ATPD-alanine--D-alanine ligase / 0.659
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.658
2pun ACPMethylthioribose kinase 2.7.1.100 0.658
2yaa ATPDeath-associated protein kinase 2 / 0.658
2pup ADPMethylthioribose kinase 2.7.1.100 0.657
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.657
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.657
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.657
3llt ANPProtein serine/threonine kinase-1 / 0.656
5drd ATPAurora kinase A 2.7.11.1 0.656
2j9g ADPBiotin carboxylase 6.3.4.14 0.655
5dr2 ATPAurora kinase A 2.7.11.1 0.655
1ol5 ADPAurora kinase A 2.7.11.1 0.654
1px2 ATPSynapsin-1 / 0.654
2hgs ADPGlutathione synthetase 6.3.2.3 0.653
3q5i ANPProtein kinase, putative / 0.653
4mam A12N5-carboxyaminoimidazole ribonucleotide synthase / 0.653
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.653
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.652
2olc ADPMethylthioribose kinase 2.7.1.100 0.652
2wq7 FADRE11660p / 0.652
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.652
5c1p ADPD-alanine--D-alanine ligase / 0.652
3cvu FADRE11660p / 0.651
4xlv ACPInsulin receptor 2.7.10.1 0.651
1jdb ADPCarbamoyl-phosphate synthase large chain / 0.650
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.650
2w5a ADPSerine/threonine-protein kinase Nek2 2.7.11.1 0.650
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.650