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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ly3 COG Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ly3 COGDihydrofolate reductase 1.5.1.3 1.014
1boz PRDDihydrofolate reductase 1.5.1.3 0.753
4dph P65Bifunctional dihydrofolate reductase-thymidylate synthase / 0.716
1mvt DTMDihydrofolate reductase 1.5.1.3 0.700
1hfp MOTDihydrofolate reductase 1.5.1.3 0.692
1hfr MOTDihydrofolate reductase 1.5.1.3 0.691
1mvs DTMDihydrofolate reductase 1.5.1.3 0.680
3eej 53RUncharacterized protein / 0.671
3td8 D2RDihydrofolate reductase 1.5.1.3 0.664
4kak 06UDihydrofolate reductase 1.5.1.3 0.659
3eek 53SUncharacterized protein / 0.656
2bl9 CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.652
4p68 MTXDihydrofolate reductase / 0.650