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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1lvl FAD Dihydrolipoyl dehydrogenase 1.8.1.4

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 1.252
2eq7 FADDihydrolipoyl dehydrogenase / 0.970
4jq9 FADDihydrolipoyl dehydrogenase / 0.967
1ger FADGlutathione reductase 1.8.1.7 0.966
1get FADGlutathione reductase 1.8.1.7 0.936
1ges FADGlutathione reductase 1.8.1.7 0.935
2hqm FADGlutathione reductase 1.8.1.7 0.930
3urh FADDihydrolipoyl dehydrogenase / 0.928
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.925
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.921
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.919
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.916
2eq6 FADDihydrolipoyl dehydrogenase / 0.916
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.910
1geu FADGlutathione reductase 1.8.1.7 0.902
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.902
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.898
2eq8 FADDihydrolipoyl dehydrogenase / 0.892
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.890
4j57 FADThioredoxin reductase 2 1.8.1.9 0.889
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.884
2yqu FADDihydrolipoyl dehydrogenase / 0.883
3lad FADDihydrolipoyl dehydrogenase / 0.879
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.876
4b1b FADThioredoxin reductase 1.8.1.9 0.874
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.867
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.863
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.857
2r9z FADGlutathione amide reductase / 0.856
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.854
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.853
2wba FADTrypanothione reductase 1.8.1.12 0.853
1zk7 FADMercuric reductase 1.16.1.1 0.846
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.836
2jk6 FADTrypanothione reductase / 0.835
2x8h FADThioredoxin glutathione reductase / 0.835
4nev FADTrypanothione reductase / 0.834
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.833
2v6o FADThioredoxin glutathione reductase / 0.831
1zx9 FADMercuric reductase 1.16.1.1 0.830
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.829
2eq9 FADDihydrolipoyl dehydrogenase / 0.829
1feb FADTrypanothione reductase 1.8.1.12 0.827
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.827
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.827
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.827
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.824
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.819
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.818
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.814
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.814
2x8g FADThioredoxin glutathione reductase / 0.811
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.811
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.804
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.801
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.800
2wow FADTrypanothione reductase / 0.799
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.795
1fea FADTrypanothione reductase 1.8.1.12 0.791
4la1 FADThioredoxin glutathione reductase / 0.791
1bzl FADTrypanothione reductase 1.8.1.12 0.788
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.788
4j56 FADThioredoxin reductase 2 1.8.1.9 0.788
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.786
2tpr FADTrypanothione reductase 1.8.1.12 0.785
1fec FADTrypanothione reductase 1.8.1.12 0.783
2zbw FADFerredoxin--NADP reductase / 0.776
1ojt FADDihydrolipoyl dehydrogenase / 0.775
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.774
1nhr FADNADH peroxidase 1.11.1.1 0.774
1f8w FADNADH peroxidase 1.11.1.1 0.772
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.772
2q7v FADThioredoxin reductase / 0.772
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.772
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.771
3nlc FADUncharacterized protein / 0.769
1tyt FADTrypanothione reductase 1.8.1.12 0.768
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.768
2rab FADGlutathione amide reductase / 0.765
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.764
2wp5 FADTrypanothione reductase / 0.763
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.762
1gxf FADTrypanothione reductase 1.8.1.12 0.758
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.755
1nhs FADNADH peroxidase 1.11.1.1 0.753
2ign FADPyranose 2-oxidase / 0.752
5buk FADFADH2-dependent halogenase / 0.751
1onf FADGlutathione reductase 1.8.1.7 0.748
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.748
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.748
4dna FADProbable glutathione reductase / 0.747
3bg7 FADPyranose 2-oxidase / 0.744
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.742
4mih FADPyranose 2-oxidase 1.1.3.10 0.742
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.739
2npx FADNADH peroxidase 1.11.1.1 0.738
1nhp FADNADH peroxidase 1.11.1.1 0.737
2igo FADPyranose 2-oxidase / 0.737
3ish FADThioredoxin reductase 1.8.1.9 0.735
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.734
2gvc FADThiol-specific monooxygenase 1.14.13 0.734
1nhq FADNADH peroxidase 1.11.1.1 0.732
3lsi FADPyranose 2-oxidase / 0.731
1typ FADTrypanothione reductase 1.8.1.12 0.729
4ap3 FADSteroid monooxygenase / 0.726
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.725
3lsh FADPyranose 2-oxidase / 0.725
3k4n FADPyranose 2-oxidase / 0.721
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.717
3cgc FADCoenzyme A disulfide reductase / 0.716
3cgd FADCoenzyme A disulfide reductase / 0.716
4opu FDAConserved Archaeal protein / 0.716
1tdf FADThioredoxin reductase 1.8.1.9 0.715
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.713
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.713
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.712
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.712
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.712
4j36 FADKynurenine 3-monooxygenase / 0.712
4rpg FADUDP-galactopyranose mutase 5.4.99.9 0.710
1cbo FADCholesterol oxidase 1.1.3.6 0.709
3f8d FADNADH oxidase/thioredoxin reductase / 0.709
4u2l SFDCholesterol oxidase 1.1.3.6 0.709
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.708
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.708
2whd FADThioredoxin reductase / 0.708
4b69 FADL-ornithine N(5)-monooxygenase / 0.707
3qfb FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.705
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.705
3cty FADProbable thioredoxin reductase / 0.704
3k4c FADPyranose 2-oxidase / 0.704
4tm3 FADKtzI / 0.703
2q0l FADThioredoxin reductase 1.8.1.9 0.702
2w0h FADTrypanothione reductase / 0.702
3cgb FADCoenzyme A disulfide reductase / 0.701
4ap1 FADSteroid monooxygenase / 0.700
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.699
3ict FADCoenzyme A disulfide reductase / 0.699
4z26 FADPutative GMC-type oxidoreductase R135 1 0.699
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.698
2xvi FADPutative flavin-containing monooxygenase / 0.698
1joa FADNADH peroxidase 1.11.1.1 0.697
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.697
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.696
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.696
4k2x FADPolyketide oxygenase/hydroxylase / 0.696
4mo2 FDAUDP-galactopyranose mutase / 0.696
1b8s FADCholesterol oxidase 1.1.3.6 0.695
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.695
3itj FADThioredoxin reductase 1 1.8.1.9 0.692
5j60 FADThioredoxin reductase / 0.692
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.691
1trb FADThioredoxin reductase 1.8.1.9 0.691
3b6d FAECholesterol oxidase 1.1.3.6 0.691
3nix FADFlavoprotein/dehydrogenase / 0.691
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.690
1mxt FAECholesterol oxidase 1.1.3.6 0.690
1n1p FADCholesterol oxidase 1.1.3.6 0.690
1n4w FADCholesterol oxidase 1.1.3.6 0.690
4mok FADPyranose 2-oxidase / 0.690
4rek FADCholesterol oxidase 1.1.3.6 0.690
4xwr FADCholesterol oxidase 1.1.3.6 0.690
4xxg FADCholesterol oxidase 1.1.3.6 0.690
3ics FADCoenzyme A disulfide reductase / 0.688
4k5r FADOxygenase / 0.688
3kyb FADUDP-galactopyranose mutase 5.4.99.9 0.687
4tlz FADKtzI / 0.687
2r0c FADPutative FAD-monooxygenase / 0.686
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.686
4u2s FDACholesterol oxidase 1.1.3.6 0.686
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.685
4aos FADSteroid monooxygenase / 0.685
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.684
4gdp FADPolyamine oxidase FMS1 / 0.684
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.683
1n4u FAECholesterol oxidase 1.1.3.6 0.682
3cnj FADCholesterol oxidase 1.1.3.6 0.682
1n4v FADCholesterol oxidase 1.1.3.6 0.681
2gew FADCholesterol oxidase 1.1.3.6 0.681
2yg3 FADPutrescine oxidase / 0.681
2yg7 FADPutrescine oxidase / 0.681
3gyi FADCholesterol oxidase 1.1.3.6 0.681
3gyj FADCholesterol oxidase 1.1.3.6 0.681
3s5w FADL-ornithine N(5)-monooxygenase / 0.681
3v76 FDAUncharacterized protein / 0.681
4fwf FADLysine-specific histone demethylase 1B 1 0.681
3ad9 FADSubunit beta of sarcosine oxidase / 0.680
2xlp FADPutative flavin-containing monooxygenase / 0.679
3cge FADCoenzyme A disulfide reductase / 0.679
4u2t FADCholesterol oxidase 1.1.3.6 0.679
3pl8 FADPyranose 2-oxidase / 0.678
1b4v FADCholesterol oxidase 1.1.3.6 0.677
1vdc FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.677
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.677
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.677
1h81 FADPolyamine oxidase 1.5.3.14 0.676
4cbq FADThioredoxin reductase / 0.676
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.675
2yg4 FADPutrescine oxidase / 0.675
2z6c FMNPhototropin-1 2.7.11.1 0.675
3kkj FADRenalase / 0.675
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.675
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.674
4ynt FDAGlucose oxidase, putative / 0.674
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.673
4j31 FADKynurenine 3-monooxygenase / 0.673
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.672
2jae FADL-amino acid oxidase / 0.672
4ccr FADThioredoxin reductase / 0.672
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.672
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.671
4gcm FADThioredoxin reductase 1.8.1.9 0.671
2yg5 FADPutrescine oxidase / 0.670
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.670
4fwe FADLysine-specific histone demethylase 1B 1 0.670
1z6l FADPolyamine oxidase FMS1 / 0.669
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.669
3he3 FADUDP-galactopyranose mutase / 0.669
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.668
4j2w FADKynurenine 3-monooxygenase / 0.668
4jn9 FADDepH / 0.668
4nwz FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.668
4qi5 FADCellobiose dehydrogenase / 0.667
2xvf FADPutative flavin-containing monooxygenase / 0.666
4gde FDAUDP-galactopyranose mutase / 0.666
4ntc FADThioredoxin reductase gliT / 0.666
4u8k FDAUDP-galactopyranose mutase / 0.666
5dbj FADFADH2-dependent halogenase PltA / 0.666
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.665
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.665
4j34 FADKynurenine 3-monooxygenase / 0.665
4qi7 FADCellobiose dehydrogenase / 0.665
4aox FADSteroid monooxygenase / 0.664
4hb9 FADUncharacterized protein / 0.664
4hsu FADLysine-specific histone demethylase 1B 1 0.664
1ijh FADCholesterol oxidase 1.1.3.6 0.663
2xvh FADPutative flavin-containing monooxygenase / 0.663
3fmw FADOxygenase / 0.663
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.663
4j33 FADKynurenine 3-monooxygenase / 0.663
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.663
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.662
3bi5 FADPolyamine oxidase FMS1 / 0.662
2bab FADPutative aminooxidase / 0.661
2rgo FADAlpha-Glycerophosphate Oxidase / 0.661
3k30 ADPHistamine dehydrogenase / 0.661
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.661
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.660
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.660
2pr5 FMNBlue-light photoreceptor / 0.660
4cnk FADL-amino acid oxidase / 0.660
4tm4 FDAKtzI / 0.660
3utf FDAUDP-galactopyranose mutase / 0.659
4qi4 FADCellobiose dehydrogenase / 0.659
1q1w FADPutidaredoxin reductase 1.18.1.5 0.658
2bac FADPutative aminooxidase / 0.658
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.658
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.657
3cox FADCholesterol oxidase 1.1.3.6 0.657
3ept FDAPutative FAD-monooxygenase / 0.657
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.657
2b9w FADPutative aminooxidase / 0.656
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.656
3r9u FADThioredoxin reductase / 0.656
4up3 FADThioredoxin reductase / 0.656
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.655
1q1r FADPutidaredoxin reductase 1.18.1.5 0.655
3utg FDAUDP-galactopyranose mutase / 0.655
4fwj FADLysine-specific histone demethylase 1B 1 0.655
4ntd FADThioredoxin reductase / 0.655
1gpe FADGlucose oxidase 1.1.3.4 0.654
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.654
4b64 FADL-ornithine N(5)-monooxygenase / 0.654
4gur FADLysine-specific histone demethylase 1B 1 0.654
5cku FADL-ornithine N(5)-monooxygenase / 0.654
1cc2 FADCholesterol oxidase 1.1.3.6 0.653
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.653
3uka FADUDP-galactopyranose mutase / 0.653
4a5l FADThioredoxin reductase / 0.653
4guu FA9Lysine-specific histone demethylase 1B 1 0.653
2ba9 FADPutative aminooxidase / 0.652
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.652
5a3b APRSIR2 family protein / 0.652
1pkv RBFRiboflavin synthase 2.5.1.9 0.651
2eq7 NADDihydrolipoyl dehydrogenase / 0.651
3jsk AHZThiamine thiazole synthase / 0.651
3t2k FADSulfide-quinone reductase / 0.651
2x3n FADProbable FAD-dependent monooxygenase / 0.650
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.650
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.650
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.650
4cnj FADL-amino acid oxidase / 0.650
4d7e FADPutative lysine-N-oxygenase / 0.650
4eep FMNPhototropin-2 2.7.11.1 0.650