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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ky8 NAP NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.315
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.219
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.147
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.121
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.116
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.064
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.890
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.835
3b4w NADAldehyde dehydrogenase family protein / 0.809
2jg7 NADAntiquitin / 0.783
4i8p NADAminoaldehyde dehydrogenase 1 / 0.781
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.773
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.773
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.766
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.764
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.757
4pz2 NADAldehyde dehydrogenase 2-6 / 0.751
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.747
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.741
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.740
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.739
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.737
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.737
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.731
4i8q NADPutative betaine aldehyde dehyrogenase / 0.728
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.725
3haz NADBifunctional protein PutA / 0.724
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.719
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.713
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.712
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.712
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.708
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.706
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.706
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.690
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.689
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.685
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.680
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.680
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.673
4pxl NADAldehyde dehydrogenase3 / 0.673
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.670
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.670
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.669
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.666
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.664
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.663
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.660
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.660
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.659
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.658
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.653
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.653
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.653
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.652