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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ky4 NAD Adenosylhomocysteinase 3.3.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ky4 NADAdenosylhomocysteinase 3.3.1.1 0.960
1b3r NADAdenosylhomocysteinase 3.3.1.1 0.862
3d64 NADAdenosylhomocysteinase / 0.819
4k28 NADShikimate dehydrogenase family protein / 0.692
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.685
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.682
3qvt NAIMyo-inositol-1-phosphate synthase (Ino1) / 0.679
1ie3 NADMalate dehydrogenase / 0.673
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.672
4njo NADD-3-phosphoglycerate dehydrogenase, putative / 0.672
1pj3 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.671
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.668
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.668
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.667
3qw2 NADMyo-inositol-1-phosphate synthase (Ino1) / 0.666
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.665
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.662
1o6z NADMalate dehydrogenase / 0.658
4xqc NADHomospermidine synthase 2.5.1.44 0.658
2o4c NADErythronate-4-phosphate dehydrogenase / 0.657
4i1i NADMalate dehydrogenase / 0.657
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.656
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.655
1efl NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.654
4jk3 NADUncharacterized protein / 0.653
4xq9 NADHomospermidine synthase 2.5.1.44 0.653
1do8 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.652
4xrg NADHomospermidine synthase 2.5.1.44 0.652
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.651