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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1kuy COT Serotonin N-acetyltransferase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1kuy COTSerotonin N-acetyltransferase / 1.481
1cjw COTSerotonin N-acetyltransferase / 1.231
1l0c COTSerotonin N-acetyltransferase / 1.206
1ib1 COTSerotonin N-acetyltransferase / 1.122
1kuv CA5Serotonin N-acetyltransferase / 0.980
1kux CA3Serotonin N-acetyltransferase / 0.969
1i12 ACOGlucosamine 6-phosphate N-acetyltransferase / 0.824
5h86 BCOHistone acetyltransferase KAT2A 2.3.1.48 0.781
4ag7 COAGlucosamine 6-phosphate N-acetyltransferase / 0.774
2qir COAAminoglycoside 6-N-acetyltransferase type Ib11 / 0.769
2cns ACORibosomal-protein-alanine acetyltransferase / 0.763
2bei ACODiamine acetyltransferase 2 2.3.1.57 0.753
2bsw CAOProbable acetyltransferase / 0.753
3exn ACOProbable acetyltransferase / 0.751
5kf1 ACOPredicted acetyltransferase / 0.747
2prb COAAminoglycoside 6-N-acetyltransferase type Ib11 / 0.742
3zj0 ACOPutative acetyltransferase OgpAT / 0.738
3vwe COAAlpha-tubulin N-acetyltransferase 1 / 0.735
1wwz ACOUncharacterized protein / 0.734
5ag5 MYAGlycylpeptide N-tetradecanoyltransferase / 0.733
1v0c ACOAAC(6')-Ib / 0.732
1tiq COASpermidine/spermine N(1)-acetyltransferase / 0.730
2cy2 ACOProbable acetyltransferase / 0.730
2cnt COARibosomal-protein-alanine acetyltransferase / 0.729
3s6f COAUncharacterized protein / 0.729
1pu9 COAHAT A1 / 0.728
2a4n COAAac(6')-Ii protein / 0.728
1bob ACOHistone acetyltransferase type B catalytic subunit / 0.727
2c27 ACOMycothiol acetyltransferase 2.3.1.189 0.726
4u9v ACON-alpha-acetyltransferase 40 2.3.1 0.726
4if5 ACOAlpha-tubulin N-acetyltransferase 1 / 0.724
1ozp ACOMycothiol acetyltransferase 2.3.1.189 0.721
1p0h ACOMycothiol acetyltransferase 2.3.1.189 0.720
2zpa ACOtRNA(Met) cytidine acetyltransferase TmcA / 0.719
5kf9 ACOPredicted acetyltransferase / 0.719
1s7n COAAcetyl transferase / 0.717
2x7b COAN-alpha-acetyltransferase 2.3.1 0.714
4r3k COAN-alpha-acetyltransferase 2.3.1 0.714
1qsn COAHAT A1 / 0.713
3te4 ACODopamine N-acetyltransferase / 0.712
4jwp ACOGCN5-related N-acetyltransferase / 0.711
2fxf ACODiamine acetyltransferase 1 / 0.709
4hkf ACOAlpha-tubulin N-acetyltransferase 1 / 0.708
5kf2 ACOPredicted acetyltransferase / 0.708
2bue COAAAC(6')-Ib / 0.707
1m4i COAAminoglycoside 2'-N-acetyltransferase 2.3.1 0.706
1qsm ACOHistone acetyltransferase HPA2 / 0.704
1pua COAHAT A1 / 0.703
1m1d LYXHAT A1 / 0.702
5kgj ACOPredicted acetyltransferase / 0.700
1p0h COAMycothiol acetyltransferase 2.3.1.189 0.699
2b3v ACODiamine acetyltransferase 1 / 0.699
4bhw 01KHistone acetyltransferase p300 / 0.699
2jdd ACOProbable acetyltransferase / 0.695
3biy 01KHistone acetyltransferase p300 / 0.695
3dr8 ACOL-methionine sulfoximine/L-methionine sulfone acetyltransferase / 0.693
3r1k COAN-acetyltransferase Eis / 0.693
2q4v ACODiamine acetyltransferase 2 2.3.1.57 0.691
1cm0 COAHistone acetyltransferase KAT2B 2.3.1.48 0.689
2b58 COADiamine acetyltransferase 1 / 0.689
4b13 NHWGlycylpeptide N-tetradecanoyltransferase / 0.687
4kvm SER_ALA_SER_GLU_1XEN-terminal acetyltransferase A complex catalytic subunit ard1 2.3.1.88 0.687
4kvx ACON-terminal acetyltransferase A complex catalytic subunit ard1 2.3.1.88 0.685
5kf2 COAPredicted acetyltransferase / 0.684
5kgh ACOPredicted acetyltransferase / 0.684
5kgp ACOPredicted acetyltransferase / 0.684
1j4j ACOAcetyltransferase 2.3.1 0.683
3r96 ACOMccE protein / 0.683
4lx9 ACON-alpha-acetyltransferase 2.3.1 0.682
4ri1 ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase 2.3.1.202 0.681
2r8v ACOAmino-acid acetyltransferase / 0.678
4crz ACOPanD regulatory factor / 0.677
4jxr ACOAcetyltransferase / 0.677
5kf8 ACOPredicted acetyltransferase / 0.677
3r95 ACOMccE protein / 0.675
3bj7 COADiamine acetyltransferase 1 / 0.674
2vbq BSJAminoglycoside N(6')-acetyltransferase type 1 / 0.673
3sxn COAN-acetyltransferase Eis / 0.673
5kf8 COAPredicted acetyltransferase / 0.672
1ghe ACOAcetyltransferase 2.3.1 0.669
2jev NHQDiamine acetyltransferase 1 / 0.669
1m4d COAAminoglycoside 2'-N-acetyltransferase 2.3.1 0.668
2y0m ACOHistone acetyltransferase KAT8 / 0.667
3fbu COAAcetyltransferase, GNAT family / 0.666
3mgd ACOPredicted acetyltransferase / 0.666
5h84 1VUHistone acetyltransferase KAT2A 2.3.1.48 0.666
1bo4 COAAminoglycoside-(3)-N-acetyltransferase / 0.665
4b5o ACOAlpha-tubulin N-acetyltransferase 1 / 0.664
1yre COAUncharacterized protein / 0.663
3f8k COAUncharacterized protein / 0.662
4h6u ACOAlpha-tubulin N-acetyltransferase 1 / 0.661
2vqy ACOAAC(6')-Ib / 0.660
4ag9 COAGlucosamine 6-phosphate N-acetyltransferase / 0.658
1z4r ACOHistone acetyltransferase KAT2A 2.3.1.48 0.657
3ryo ACON-acetyltransferase Eis / 0.656
1s3z COAAminoglycoside N(6')-acetyltransferase type 1 / 0.655
2psw COAN-alpha-acetyltransferase 50 / 0.655
3vwd ACOAlpha-tubulin N-acetyltransferase 1 / 0.655
1b87 ACOAac(6')-Ii protein / 0.654