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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1kmv LII Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1kmv LIIDihydrofolate reductase 1.5.1.3 0.960
1kms LIHDihydrofolate reductase 1.5.1.3 0.773
2w3w VG9Dihydrofolate reductase / 0.702
3jw3 TOPDihydrofolate reductase / 0.688
3fre TOPDihydrofolate reductase 1.5.1.3 0.680
2w9g TOPDihydrofolate reductase 1.5.1.3 0.679
3eig MTXDihydrofolate reductase 1.5.1.3 0.677
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.669
1ohj COPDihydrofolate reductase 1.5.1.3 0.666
2fzj DH3Dihydrofolate reductase 1.5.1.3 0.658