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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1klk PMD Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1klk PMDDihydrofolate reductase 1.5.1.3 0.927
3sai 9DRDihydrofolate reductase / 0.687
3s7a 684Dihydrofolate reductase 1.5.1.3 0.682
1u70 MTXDihydrofolate reductase 1.5.1.3 0.677
1dls MTXDihydrofolate reductase 1.5.1.3 0.668
3gyf 51PDihydrofolate reductase 1.5.1.3 0.667
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.660
4elf 35IDihydrofolate reductase / 0.658
1dra MTXDihydrofolate reductase 1.5.1.3 0.650